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Conformational Studies of Cyclotetradepsipeptides and Analogues Related To Serratamolide

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Molecular and Quantum Pharmacology

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 7))

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Abstract

Serratamolide is a cyclotetradepsipeptide isolated from serratia marcescens, with the structure (I), composed of two molecules of D-3-hydroxy decanoic acid and two of L-serine coupled as shown [1]. The mild antibiotic activity of this molecule depends on the length of the hydrocarbon side chain, in that the activity increases when the chain length is increased, and vice versa [2].

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References

  1. Wasserman, H. H., Keggi, J. J., and McKeon, J. E.: J. Am. Chem. Soc. 84, 2978 (1962).

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  2. Hassall, C. H., Sanger, D. G., and Thomas, J. O.: Peptides-Proc. of the 9th European Peptide Symposium, North Holland, 1968, p. 70.

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  3. Hassall, C. H., Moschidis, M. C., and Thomas, W. A.: J. Chem. Soc. B, 1757 (1971).

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  4. Talekar, S. V.: Studia Biophysica, Berlin 38229 (1973).

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© 1974 D. Reidel Publishing Company, Dordrecht-Holland

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Thomas, W.A. (1974). Conformational Studies of Cyclotetradepsipeptides and Analogues Related To Serratamolide. In: Bergmann, E.D., Pullman, B. (eds) Molecular and Quantum Pharmacology. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1758-9_22

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  • DOI: https://doi.org/10.1007/978-94-010-1758-9_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-1760-2

  • Online ISBN: 978-94-010-1758-9

  • eBook Packages: Springer Book Archive

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