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Molecular and Quantum Pharmacology

Proceedings of the Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, March 31st–April 4th, 1974

  • Conference proceedings
  • © 1974

Overview

Editors:
  1. Ernst D. Bergmann

    1. Department of Organic Chemistry, The Hebrew University, Jerusalem, Israel

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  2. Bernard Pullman

    1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Université de Paris, Paris, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Jerusalem Symposia (JSQC, volume 7)

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Table of contents (41 papers)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. Introductory Remarks On Pharmacological Receptors

    • Felix Bergmann
    Pages 1-7

  3. The Adventures of a Quantum-Chemist in the Kingdom of Pharmacophores

    • Bernard Pullman
    Pages 9-36

  4. Quantitative Structure-Activity Relationships

    • W. P. Purcell
    Pages 37-41

  5. Imidazole Tautomerism of Histamine Derivatives

    • C. R. Ganellin
    Pages 43-53

  6. The Conformation of Histamine, 5-Hydroxytryptamine and Some Related Derivatives in Aqueous Solution

    • R. R. Ison
    Pages 55-66

  7. Molecular Orbital Calculations On Catecholamines; Theory and Experiment

    • Robert Katz, Stephen R. Heller, A. E. Jacobson, A. Rotman, C. R. Creveling
    Pages 67-76

  8. The Conformation of Catecholamines in Solution

    • G. C. K. Roberts
    Pages 77-93

  9. Molecular Factors and Activity in Psychopharmacologically Active Compounds

    • Ernst D. Bergmann, Edna Oppenheimer, Hannah Weiler-Feilchenfeld, Sasson Cohen
    Pages 95-103

  10. An Approach To Possible Correlations Between Activity And Conformation In Some Classes Of Psychotropic Drugs

    • Alan S. Horn, Olga Kennard, W. D. S. Motherwell, Michael L. Post, John R. Rodgers
    Pages 105-118

  11. Studies of the Conformation in Solution of Molecules Related to Acetylcholine

    • Henry G. Mautner
    Pages 119-129

  12. Solvent-Dependent Conformational Studies of Acetylcholine and Some Related Molecules

    • H. J. R. Weintraub, A. J. Hopfinger
    Pages 131-152

  13. Theoretical Studies of Solvent Effects on the Conformational Stability of Cholinergic Molecules

    • David L. Beveridge, Richard J. Radna, Gary W. Schnuelle, Margaret M. Kelly
    Pages 153-178

  14. Conformational Isomerism in Drug Action: Does the Free Energy of Binding Induce the Pharmacophoric Conformation of Semi-Rigid Muscarinic Agonists?

    • G. Lambrecht, E. Mutschler
    Pages 179-187

  15. Studies on the Cholinergic Receptor of Squid Optic Ganglia

    • G. Kato, B. Tattrie
    Pages 189-209

  16. Squid Nerve Type DFPase: A Consideration of Molecular Structures

    • Francis C. G. Hoskin
    Pages 209-211

  17. Stereochemical Similarities in Chemically Different Antiepileptic Drugs

    • Arthur Camerman, Norman Camerman
    Pages 213-228

  18. Molecular Orbital Calculations on Anti-Epileptic Compounds

    • Haven S. Aldrich, Lemont B. Kier
    Pages 229-240

  19. A Conformational Study of Antihistaminic Pheniramines in Solution

    • Bernard Testa
    Pages 241-259

  20. NMR Studies of Solution Conformations of Physiologically Active Amino-Acids

    • Norman S. Ham
    Pages 261-268
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Keywords

About this book

The seventh Jerusalem Symposium has tried to penetrate into a field of research towards which the efforts of a large number of the most variegated modern techniques are conversing: molecular and quantum pharmacology. The hope to elucidate the mode of action of drugs, to establish correlations between the electronic and con­ formational structures of drugs and their mode of action and level of activity, to derive from these data the nature of the cellular receptors and an understanding of the interaction of the drugs with those receptors - is a strong stimulus to enlarge and deepen the research efforts with the ultimate view to rationalize the design of more efficient and more specific drugs. The Symposium represents an attempt to survey the progress made so far in this respect and the methods and efforts employed in order to arrive at even greater achievements. The presentation of this Symposium differs somewhat from that of the preceding ones. Owing to the political events which disturbed the peace in the Middle East and therefore the normal activities of commerce and industry in Israel at least temporarily, the printing and distribution of this volume were entrusted to the Reidel Publishing Company. We wish to thank them for their very efficient col1aboration and for all their efforts to publish this volume with a minimum delay.

Editors and Affiliations

  • Department of Organic Chemistry, The Hebrew University, Jerusalem, Israel

    Ernst D. Bergmann

  • Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Université de Paris, Paris, France

    Bernard Pullman

Bibliographic Information

  • Book Title: Molecular and Quantum Pharmacology

  • Book Subtitle: Proceedings of the Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, March 31st–April 4th, 1974

  • Editors: Ernst D. Bergmann, Bernard Pullman

  • Series Title: Jerusalem Symposia

  • DOI: https://doi.org/10.1007/978-94-010-1758-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: D. Reidel Publishing Company, Dordrecht, Holland 1974

  • Hardcover ISBN: 978-90-277-0525-9Published: 28 February 1975

  • Softcover ISBN: 978-94-010-1760-2Published: 12 October 2011

  • eBook ISBN: 978-94-010-1758-9Published: 06 December 2012

  • Series ISSN: 0924-4875

  • Edition Number: 1

  • Number of Pages: IX, 591

  • Topics: Physical Chemistry

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