Cutaneous Melanoma and Precursor Lesions

1. Front Matter

   Pages I-XII

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2. Fundamental Aspects

   1. The Epidemiology of Melanoma

      • R. M. MacKie

      Pages 1-8

   2. The Molecular Biology of Carcinogenesis

      • A. W. M. Van Der Kamp, N. G. J. Jaspers

      Pages 9-18

   3. Human Melanoma Associated Antigens Identified with Monoclonal Antibodies: Characterization and Potential Clinical Application

      • P. G. Natali, R. Cavaliere, M. Matsui, G. Buraggi, L. Callegaro, S. Ferrone

      Pages 19-37

   4. Cellular and Molecular Parameters of Tumor Progression in Human Malignant Melanoma

      • J. Brüggen, E.-B. Bröcker, L. Suter, K. Redmann, C. Sorg

      Pages 38-56

   5. Immune Responses to Human Malignant Melanoma

      • J. E. De Vries

      Pages 57-71

3. Diagnosis and Prognostic Factors

   1. Clinical Diagnosis of Cutaneous Melanomas

      • W. A. van Vloten

      Pages 72-80

   2. Patient’s and Doctor’s Delay in Diagnosing and Treating Malignant Melanoma of the Skin

      • F. H. J. Rampen, Ph Rümke

      Pages 81-96

   3. Histopathology of Cutaneous Malignant Melanoma

      • E. P. Van Der Esch

      Pages 97-111

   4. Immunohistopathological Aspects of Cutaneous Melanoma and Precursor Lesions

      • D. J. Ruiter, S. G. van Duinen, S. O. Warnaar

      Pages 112-125

   5. Prognostic Factors for Cutaneous Melanoma

      • A. J. Sober

      Pages 126-142

4. Treatment

   1. Incidence of Recurrence and Survival in Clinical Stage I Patients With Melanoma After Local Excision

      • K. Welvaart, D. J. A. Van Kampen, J. Hermans, W. Felthuis, J. Van Den Heuvel, P. L. De Jong

      Pages 143-164

   2. Long Term Results of Randomized Trial Comparing Immediate Versus Delayed Node Dissection in Stage I Melanoma of the Limbs

      • U. Veronesi, R. Bufalino, N. Cascinelli, A. Morabito

      Pages 165-180

   3. Local Excision and Regional Perfusion in High-Risk Stage-I Malignant Melanoma of the Extremities

      • H. Schraffordt Koops, J. Oldhoff, M. Nap, J. W. Oosterhuis, H. Beekhuis

      Pages 181-189

   4. The Use of Chemotherapy in the Management of Patients with Malignant Melanoma

      • Ph. Rümke

      Pages 190-212

   5. Radiotherapy of Malignant Melanoma

      • E. M. Noordijk

      Pages 213-218

5. Precursor Lesions

   1. Congenital Nevocellular Nevi

      • B. Konz

      Pages 219-226

   2. Clinical Aspects of Dysplastic Nevus Syndrome

      • W. Bergman, A. Palan, L. N. Went

      Pages 227-238

   3. Histopathological Aspects of Dysplastic Nevi

      • D. J. Ruiter, W. Bergman, P. M. Steylen, E. Scheffer

      Pages 239-248

   4. Critical Remarks on the Dysplastic Naevus Syndrome

      • R. M. MacKie

      Pages 249-252

In recent years much progress has been made in knowledge and understanding of the biology of cutaneous melanoma. In this respect etiological factors, prognostic factors, antigen expression of melanoma cells, immune response and mechanisms of metastasis formation have to be mentioned. It is the purpose of this book to give a review on fundamental aspects, diagnosis and prognosis, and treatment of cutaneous melanoma and precursor lesions. Moreover, previously unpublished new data are presented. A post-graduate Boerhaave course "Cutaneous Melanoma and Precursor Lesions" was held at Leiden University on 12 and 13 April,. 1984. The proceedings are contained in this volume. The editors would like to thank all speakers and chairpersons on the course, the Boerhaave Committee for its contribution to the organisation of the course, Upjohn Nederland for its financial support and Mrs. I.A. Kruyff for her secretarial assistance. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII List of First Authors with Co-Authors XI PART I: FUNDAMENTAL ASPECTS. The epidemiology of melanoma R.M. MACKIE The molecular biology of carcinogenesis 9 A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human melanoma associated antigens identified with monoclonal antibodies: characterization and potential clinical application P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE Cellular and molecular parameters of tumor progression in 38 human malignant melanoma J. BRUEGGEN, E.B. BROECKER, L. SUTER, K. REDMANN, and C.

• carcinogenesis
• histopathology
• melanoma
• molecular biology
• pathology
• radiotherapy
• tumor
• tumor progression

• Department of Pathology, University Medical Center, Leiden, The Netherlands

  Dirk J. Ruiter

• Department of Pathology, Faculty of Medicine, University of Leiden, Leiden, The Netherlands

  Dirk J. Ruiter

• Department of Surgical Oncology, University Medical Center, Leiden, The Netherlands

  Kees Welvaart

• Department of Surgery, University Hospital, Leiden, The Netherlands

  Kees Welvaart

• Department of Microbiology and Immunology, New York Medical College, Valhalla, USA

  Soldano Ferrone

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