Abstract
Technetium-99m has nearly optimal characteristics as a radionuclide for diagnostic radiopharmaceuticals: (1) a low radiation dose to the patients due to the absence of a-and β-radiation and the short physical half-life (6.02 h), (2) the excellent quality of its scintigraphic images as a result of the favourable energy of its gamma radiation (140.5 keV) which is efficiently detected by the Nal(T1) crystals of conventional gamma cameras and on the other hand has a good tissue penetration and (3) its continuous availability as pertechnetate from a 99mMo- 99mTc generator. However, an inconvenience associated with technetium is the fact that it cannot simply replace a hydrogen atom as it is the case with halogens like 123I and 18F, nor can be a substitute for one of the other common atoms in biologically interesting compounds, i.e. carbon, nitrogen or oxygen.
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Verbruggen, A.M. (1996). Bifunctional Chelators for Technetium-99m. In: Mather, S.J. (eds) Current Directions in Radiopharmaceutical Research and Development. Developments in Nuclear Medicine, vol 30. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1768-2_2
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DOI: https://doi.org/10.1007/978-94-009-1768-2_2
Publisher Name: Springer, Dordrecht
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