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Transcriptional and Translational Regulation of Stem Cells

  • Book
  • © 2013

Overview

Editors:
  1. Gary Hime

    1. , Anatomy and Neuroscience, University of Melbourne, Parkville, Australia

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    You can also search for this editor in PubMed   Google Scholar

  2. Helen Abud

    1. , Anatomy and Developmental Biology, Monash University, Clayton, Australia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Latest research in stem cell regulation
  • Stem cells from various species are discussed providing a unique overview of stem cell biology
  • The regulators of stem cells provide new candidates for disease therapy

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 786)

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About this book

This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The Stem Cell State

    • Gary R. Hime, Helen E. Abud
    Pages 1-4

  3. Induction of Pluripotency

    • Corey Heffernan, Jun Liu, Huseyin Sumer, Luis F. Malaver-Ortega, Rajneesh Verma, Edmund Carvalho et al.
    Pages 5-25

  4. Model Stem Cell Systems (A) Invertebrate

    1. Front Matter

      Pages 27-27
      Download chapter PDF

    2. Germline Stem Cells and Their Regulation in the Nematode Caenorhabditis elegans

      • Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter, Judith Kimble
      Pages 29-46

    3. Transcriptional and Post-transcriptional Regulation of Drosophila Germline Stem Cells and Their Differentiating Progeny

      • Helen White-Cooper, Simona Caporilli
      Pages 47-61

    4. Stem Cells in the Drosophila Digestive System

      • Xiankun Zeng, Chhavi Chauhan, Steven X. Hou
      Pages 63-78

    5. Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System

      • Rita Sousa-Nunes, W. Gregory Somers
      Pages 79-102

  5. Model Stem Cell Systems (B) Vertebrate

    1. Front Matter

      Pages 103-103
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    2. Transcriptional/Translational Regulation of Mammalian Spermatogenic Stem Cells

      • Cathryn A. Hogarth
      Pages 105-128

    3. Transcriptional Regulation and Specification of Neural Stem Cells

      • Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate, Ann M. Turnley
      Pages 129-155

    4. Transcriptional Control of Epidermal Stem Cells

      • Briana Lee, Xing Dai
      Pages 157-173

    5. Regulation of Intestinal Stem Cells by Wnt and Notch Signalling

      • Katja Horvay, Helen E. Abud
      Pages 175-186

    6. Transcriptional Regulation of Haematopoietic Stem Cells

      • Adam C. Wilkinson, Berthold Göttgens
      Pages 187-212

    7. Regulation of Mesenchymal Stem Cell Differentiation

      • David Cook, Paul Genever
      Pages 213-229

  6. Molecular Families Implicated in Stem Cell Regulation

    1. Front Matter

      Pages 231-231
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    2. The Musashi Family of RNA Binding Proteins: Master Regulators of Multiple Stem Cell Populations

      • Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime, Nicole A. Siddall
      Pages 233-245

    3. JAK-STAT Signaling in Stem Cells

      • Rachel R. Stine, Erika L. Matunis
      Pages 247-267

    4. Myc in Stem Cell Behaviour: Insights from Drosophila

      • Leonie M. Quinn, Julie Secombe, Gary R. Hime
      Pages 269-285

    5. The Role of Nuclear Receptors in Embryonic Stem Cells

      • Qin Wang, Austin J. Cooney
      Pages 287-306
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Editors and Affiliations

  • , Anatomy and Neuroscience, University of Melbourne, Parkville, Australia

    Gary Hime

  • , Anatomy and Developmental Biology, Monash University, Clayton, Australia

    Helen Abud

Bibliographic Information

  • Book Title: Transcriptional and Translational Regulation of Stem Cells

  • Editors: Gary Hime, Helen Abud

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-94-007-6621-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 2013

  • Hardcover ISBN: 978-94-007-6620-4Published: 06 June 2013

  • Softcover ISBN: 978-94-024-0182-0Published: 27 August 2016

  • eBook ISBN: 978-94-007-6621-1Published: 22 May 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 371

  • Number of Illustrations: 8 b/w illustrations, 53 illustrations in colour

  • Topics: Biomedicine general, Stem Cells, Cell Biology, Developmental Biology

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