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Macrophage Differentiation and Activation States in the Tumor Microenvironment

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Book cover The Tumor Immunoenvironment

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Abstract

Macrophages are amongst the most plastic cells of the body, contributing to organogenesis and tissue homeostasis and regulating the balance between pro- and anti-inflammatory reactions. To accommodate these different functions, macrophages are notoriously heterogeneous and are able to adopt different activation states in response to a changing microenvironment. Accumulating evidence exists that macrophages contribute to all phases of the cancer process. These cells are central players in inflammation-associated carcinogenesis, participate in tumor immunosurveillance, and are involved in tumor progression and metastasis. Inside tumors, tumor-associated macrophages (TAM) are confronted with different tumor microenvironments, leading to TAM subsets with distinct activation states and specialized functions. A better refinement of the molecular and functional heterogeneity of tumor-associated macrophages might pave the way for novel cancer therapies that directly target these tumor-supporting cells.

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  1. Laboratory of Cellular and Molecular Immunology, Myeloid Cell Immunology Laboratory, VIB-Vrije Universiteit Brussel, Building E, Level 8, Pleinlaan 2, 1050, Brussels, Belgium

    Jo A. Van Ginderachter

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  1. Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street Scaife Hal, Pittsburgh, 15213, Pennsylvania, USA

    Michael R. Shurin

  2. , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Viktor Umansky

  3. , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Post Office B, Frederick, 21702, Maryland, USA

    Anatoli Malyguine

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Van Ginderachter, J.A. (2013). Macrophage Differentiation and Activation States in the Tumor Microenvironment. In: Shurin, M., Umansky, V., Malyguine, A. (eds) The Tumor Immunoenvironment. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6217-6_17

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