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The Warburg Effect Is a Guide to Multipurpose Cancer Therapy Including Trace Element Delivery

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Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 4))

Abstract

The Nobel Prize Winner (1931) Dr. Otto H. Warburg had established that the main energy source of the cancer cell is aerobic glycolysis (the Warburg effect). He also postulated the hypothesis about “the prime cause of cancer”, which is a matter of debate till nowadays. On the contrary to the hypothesis, his discovery was completely recognized. However, the discovery had been almost vanished in the heat of battle about the hypothesis. The prime cause of cancer is important for the prevention and diagnosis, and yet the effects that influence on tumor growth are more important for cancer treatment. As a consequence of the Warburg effect, the recovery of the oxygen respiration of cancer cells can inhibit the tumor growth and lead to a remission. Here, we review the current knowledge of the inhibition of abnormal glycolysis and normalization of oxygen respiration of malignant tumor and a potential role of ultra trace element germanium in this process. Efficiency of different Ge-delivery molecules is also discussed.

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Acknowledgements

Supported in part (AVP) by Grant #IRG-78-002-31 from the American Cancer Society.

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Authors and Affiliations

  1. Department of Radiology, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA, 19104, USA

    Anatoliy V. Popov

  2. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    Leonid G. Menchikov

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  1. Anatoliy V. Popov
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  2. Leonid G. Menchikov
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Correspondence to Anatoliy V. Popov or Leonid G. Menchikov .

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  1. , Chemical Engineering, University of Coimbra, Rua Silvio Lima, Coimbra, 3030 790, Portugal

    Jorge Coelho

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Popov, A.V., Menchikov, L.G. (2013). The Warburg Effect Is a Guide to Multipurpose Cancer Therapy Including Trace Element Delivery. In: Coelho, J. (eds) Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment. Advances in Predictive, Preventive and Personalised Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6010-3_9

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