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Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses

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Electric Cell-Substrate Impedance Sensing and Cancer Metastasis

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 17))

Abstract

Interaction between tumour cells and endothelial cells is an essential step during the systemic step of cancer metastasis in the body and has been an active area pursued for the past decades. However, methods to investigate tumour-endothelial interactions mostly are tedious and lack of high throughput capability. Similarly, tumour-mesothelial interactions are also important part of the transcoelomic spreading in the body cavities. However, methods to determine tumour-mesothelial interaction face similar challenges to that of tumour-endothelial interactions. This chapter discusses the application of electric cell-substrate impedance sensing (ECIS) in the investigation of tumour-endothelial/mesothelial interactions.

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Acknowledgement

The authors wish to thank Cancer Research Wales, Albert Hung Foundation, Breast Cancer Hope Foundation and Robert Benjamin Ablin Cancer Foundation for supporting their work.

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Authors and Affiliations

  1. Institutes of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK

    Wen G. Jiang, Lin Ye & Malcolm D. Mason

  2. Department of Gynaecology and Obstetrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Haiying Ren

  3. The TIME Institute, Cardiff University School of Medicine, Cardiff, UK

    Ann Kift-Morgan & Nicholas Topley

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  1. Wen G. Jiang
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  2. Lin Ye
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  3. Haiying Ren
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  4. Ann Kift-Morgan
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  5. Nicholas Topley
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  6. Malcolm D. Mason
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Corresponding author

Correspondence to Wen G. Jiang .

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Editors and Affiliations

  1. Research Group Dept. Of Surgery College, Of Medicine, Univ.Of Wales Metastatis, Heath Park, Cardiff, CF4 4XN, United Kingdom

    Wen G. Jiang

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Jiang, W.G., Ye, L., Ren, H., Kift-Morgan, A., Topley, N., Mason, M.D. (2012). Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses. In: Jiang, W. (eds) Electric Cell-Substrate Impedance Sensing and Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4927-6_9

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