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Calcium Signaling pp 511–520Cite as

Calcium Oscillations and Pacemaking

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Calcium plays important role in biological systems where it is involved in diverse mechanisms such as signaling, muscle contraction and neuromodulation. Action potentials are generated by dynamic interaction of ionic channels located on the plasma-membrane and these drive the rhythmic activity of biological systems such as the smooth muscle and the heart. However, ionic channels are not the only pacemakers; an intimate interaction between intracellular Ca2+ stores and ionic channels underlie rhythmic activity. In this review we will focus on the role of Ca2+ stores in regulation of rhythmical behavior.

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Abbreviations

IP3 :

Inositol 1,4,5-trisphosphate

CICR:

Ca2+-induced-Ca2+ release

ER:

Endoplasmic reticulum

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Authors and Affiliations

  1. Department of Physiology & Pharmacology, Faculty of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada

    Mohammad S. Imtiaz

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Correspondence to Mohammad S. Imtiaz .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Imtiaz, M.S. (2012). Calcium Oscillations and Pacemaking. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_22

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