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Dealing with Contaminated Sites pp 287–324Cite as

Oral Bioavailability

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Abstract

Soil ingestion is a key exposure pathway in Human Health Risk Assessment for contaminants in soil. The theory and mechanisms of how contaminants in a soil enter the human body through the gastrointestinal tract are outlined. The methods available for measuring human exposure using human, animal and validated in-vitro laboratory methods are described and contrasted. The role of the physico-chemical properties of the soils that control the bioavailability of contaminants are summarised. Finally, examples of how bioavailability/bioaccessibility studies of soils from both anthropogenic and geogenic origin are discussed along with the criteria required for deciding whether bioavailability data should be used in a Human Health Risk Assessment.

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Authors and Affiliations

  1. British Geological Survey, Keyworth, Nottingham, UK

    Mark R. Cave & Joanna Wragg

  2. National Institute of Industrial Environment and Risks (INERIS), Verneuil-en-Halatte, France

    Sébastien Denys

  3. University of Nancy, Nancy, France

    Catherine Jondreville & Cyril Feidt

Authors
  1. Mark R. Cave
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  2. Joanna Wragg
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  3. Sébastien Denys
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  4. Catherine Jondreville
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  5. Cyril Feidt
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Correspondence to Mark R. Cave .

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  1. National Institute of Public Health and, Bilthoven, 3720 BA, Netherlands

    Frank A. Swartjes

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Cave, M.R., Wragg, J., Denys, S., Jondreville, C., Feidt, C. (2011). Oral Bioavailability. In: Swartjes, F. (eds) Dealing with Contaminated Sites. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9757-6_7

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