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The calcitonin gene-related peptide family

form, function and future perspectives

  • Book
  • © 2010

Overview

Editors:
  1. Deborah L. Hay

    1. School of Biological Sciences, University of Auckland, Auckland , New Zealand

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    You can also search for this editor in PubMed   Google Scholar

  2. Ian M. Dickerson

    1. University of Auckland, Auckland, New Zealand

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    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive compilation of reviews on CGRP, amylin, calcitonin, adrenomedullin and AM2/intermedin
  • Useful reference work for researchers in the fields of CGRP, amylin, calcitonin, adrenomedullin and AM2/intermedin

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Molecular and Functional Evolution of the Adrenomedullin Family in Vertebrates: What Do Fish Studies Tell Us?

    • Yoshio Takei, Maho Ogoshi, Marty K. S. Wong, Shigenori Nobata
    Pages 1-21

  3. Ligand Binding and Activation of the CGRP Receptor

    • James Barwell, John Simms, Alex Conner, Debbie Hay, Mark Wheatley, David Poyner
    Pages 23-40

  4. Understanding Amylin Receptors

    • Rasmus Just, John Simms, Sebastian G. B. Furness, Arthur Christopoulos, Patrick M. Sexton
    Pages 41-57

  5. The CGRP-Receptor Component Protein: A Regulator for CLR Signaling

    • Ian Dickerson
    Pages 59-73

  6. The Calcitonin Peptide Family: What Can We Learn from Receptor Knock Out and Transgenic Mice

    • Walter Born, Jan A. Fischer
    Pages 75-86

  7. Gene Targeted Mouse Models of Adrenomedullin Signaling

    • Mahita Kadmiel, Kathleen M. Caron
    Pages 87-95

  8. Genetic Regulation of CGRP and Its Actions

    • Ki-Youb Park, Andrew F. Russo
    Pages 97-114

  9. Vascular Actions of CGRP and Adrenomedullin: Mechanisms and Potential Contribution to Inflammation in the Cutaneous Microvasculature

    • Gabor Pozsgai, Lihuan Liang, Susan D. Brain
    Pages 115-130

  10. Insights into the Function of Intermedin/Adrenomedullin 2

    • Chia Lin Chang, Sheau Yu Teddy Hsu
    Pages 131-149

  11. CGRP and Adrenomedullin as Pain-Related Peptides

    • Weiya Ma, Jean-Guy Chabot, Ara Schorscher-Petcu, Yinguo Hong, Zhiyong Wang, Remi Quirion
    Pages 151-171

  12. Amylinergic Control of Ingestive Behaviour

    • Thomas A. Lutz
    Pages 173-184

  13. CGRP Receptor Antagonists for Migraine: Challenges and Promises

    • Christopher A. Salvatore, Stefanie A. Kane
    Pages 185-197

  14. Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues: Developmental and Pathophysiological Implications

    • P.J. Wookey, A. Zulli, C. Lo, D. L. Hare, A. P. Schwarer, I. A. Darby et al.
    Pages 199-233

  15. Conclusions and Future Perspectives

    • Debbie L. Hay
    Pages 235-236
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Keywords

About this book

In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

Editors and Affiliations

  • School of Biological Sciences, University of Auckland, Auckland , New Zealand

    Deborah L. Hay

  • University of Auckland, Auckland, New Zealand

    Ian M. Dickerson

Bibliographic Information

  • Book Title: The calcitonin gene-related peptide family

  • Book Subtitle: form, function and future perspectives

  • Editors: Deborah L. Hay, Ian M. Dickerson

  • DOI: https://doi.org/10.1007/978-90-481-2909-6

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2010

  • Hardcover ISBN: 978-90-481-2908-9Published: 14 October 2009

  • Softcover ISBN: 978-94-007-9180-0Published: 02 November 2014

  • eBook ISBN: 978-90-481-2909-6Published: 03 October 2009

  • Edition Number: 1

  • Number of Pages: VIII, 236

  • Topics: Biomedicine general, Endocrinology, Gene Expression, Cancer Research

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