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Human Adult Stem Cells pp 197–208Cite as

Prostate

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Part of the book series: Human Cell Culture ((HUCC,volume 7))

Abstract

Evidence for stem cells in the adult prostate comes from studies performed in rodents. Isaacs and Coffey [20] showed that castration in male rats resulted in the involution of prostate gland with persistence of the basal layer. On replacement of androgens, the prostate regained its original size [20]. It was concluded that a population of cells in the basal layer is capable of reconstituting the prostate in the presence of androgens. Since then good evidence of the existence and characterization of stem or stem like cells has been shown for mouse prostate [2, 23, 58]. Stem-like cells have also been described in cell lines derived from human prostate [34, 46] and from transplantation studies of human malignant prostate in mice [35]. In contrast to some tissues [10, 11, 28, 48, 49], isolation and characterization of stem cells from freshly procured human prostate tissue has proved difficult. Although there are numerous studies that have attempted to isolate, propagate and characterize human prostate derived stem cells; conclusive evidence for the existing of self-renewing, multipotential human prostate stem cells has proved elusive [46].

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Author information

Authors and Affiliations

  1. Division of Surgery and Interventional Sciences, Charles Bell House Laboratories, Prostate Cancer Research Centre, University College London, 67 Riding House Street, London, UK

    C. Foley, K.T. Brouilette, C. Kane, H. Patel, H. Yamamoto & A. Ahmed

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  1. C. Foley
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  2. K.T. Brouilette
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  3. C. Kane
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  4. H. Patel
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  5. H. Yamamoto
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  6. A. Ahmed
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Editor information

Editors and Affiliations

  1. University College London Inst. Urology & Nephrology, 67 Riding House Street, London, United Kingdom W1P 7PN

    John R. Masters

  2. Dept. Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0412, USA

    Bernhard Ø. Palsson

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Foley, C., Brouilette, K., Kane, C., Patel, H., Yamamoto, H., Ahmed, A. (2009). Prostate. In: Masters, J.R., Palsson, B.Ø. (eds) Human Adult Stem Cells. Human Cell Culture, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2269-1_10

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