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Anatomy of Tetralogy of Fallot

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The Right Ventricle in Adults with Tetralogy of Fallot

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Abstract

It was Etienne-Louis Arthur Fallot who, in 1888, first described the clinicopathological correlates of the “maladie bleue” [1]. The lesion that he identified was the association of interventricular communication, sub pulmonary stenosis, biventricular origin of the aorta and hypertrophy of the right ventricle. From the translation in English by Allwork in 1988 [2], come the following significant passages of Fallot's original work:

... during the last few years, three cases of a rare and curious disease have passed before our eyes.observed during their lives and afterwards at necropsy, three patients affected by the illness called “maladie bleue”.

... we thought that the “maladie bleue” was caused by these lesions multiple but constant, so together they constituted a type perfectly defined.

All the three patients had... an abnormal interventricular communication and in each of them the ventricular septal defect was in the same place, the superior part of the septum...the pulmonary artery was narrowed and in each there was subarterial as well as valvular stenosis...there was ventricular hypertrophy...the aorta deviated to the right...took equal origin from both ventricles.”

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References

  1. Fallot A (1888) Contribution a l'anatomie patologique de la maladie bleue (cyanose cardiaque). Marseille Med 25:77-93

    Google Scholar 

  2. Allwork SP (1988) Tetralogy of Fallot: the centenary of the name. A new translation of the first of Fallot's papers. Eur J Cardio Thorac Surg 2:368-392

    Article  Google Scholar 

  3. Marquis RM (1956) Longevity and the early history of the tetralogy of Fallot. Br Med J 1:819-822

    Article  PubMed  CAS  Google Scholar 

  4. Stenonis N (1671-1672) Embryo monstro affinis Parisii dissectus. Acta Medica et Philosophica Hafniensia 1:200-203

    Google Scholar 

  5. Farre JR (1914) Pathological researches. Essay 1. On the malformation of the heart. Longman, Hurst, Rees, Orm and Brown, London, p 21

    Google Scholar 

  6. Peacock TB (1866) Malformation of the heart, 2 edn. Churchill, London 35:58-60

    Google Scholar 

  7. Von Rokitansky KF (1875) Die Defekte der Scheidewand des Herzens. PathologischAnatomisch Wilhelm Braunmüller, Vienna, pp 27–29

    Google Scholar 

  8. Abbott ME, Dawson WT (1924) The clinical classification of congenital heart disease, with remarks upon its pathological anatomy, diagnosis and treatment. Int Clin 4:156-188

    Google Scholar 

  9. Abbott ME (1936) Atlas of congenital cardiac disease. Am Heart Association, New York, pp 46–47

    Google Scholar 

  10. Lev M, Eckner FAO (1964) The pathologic anatomy of tetralogy of Fallot and its variants. Dis Chest 45:251-261

    Article  PubMed  CAS  Google Scholar 

  11. Lev M, Rimoldi HJA, Rowlatt UF (1964) The quantitative anatomy of cyanotic tetralogy of Fallot. Circulation 30:531-538

    Article  PubMed  CAS  Google Scholar 

  12. Becker A, Connor M, Anderson RH (1975) Tetralogy of Fallot: a morphometric and geometric study. Am J Cardiol 35:402-412

    Article  PubMed  CAS  Google Scholar 

  13. Anderson RH, Allwork SP, Ho SY et al (1981) Surgical anatomy of tetralogy of Fallot. J Thorac Cardiovasc Surg 81:887-896

    PubMed  CAS  Google Scholar 

  14. Anderson RH, Tynan M (1988) Tetralogy of Fallot-a centennial review. Int J Cardiol 21:219-232

    Article  PubMed  CAS  Google Scholar 

  15. Ho SY, Anderson RH (1990) The modern assessment of tetralogy of Fallot: morphological aspects. Chir Torac 43:101-110

    Google Scholar 

  16. Eisenmenger V (1897) Die angeborenen Defekte der Kammerscheidewand des Herzen. Z Klin Med 32:1-28

    Google Scholar 

  17. Oppenheimer-Dekker A, Gittenberger De Groot AC, Bartelings MM et al (1985) Abnormal architecture of the ventricles in hearts with an overriding aortic valve and a perimembranous ventricular septal defect (”Eisenmenger VSD”). Int J Cardiol 9:341-355

    Article  PubMed  CAS  Google Scholar 

  18. Anderson RH, Weinberg PM (2005) The clinical anatomy of tetralogy of Fallot. Cardiol Young 15:38-47

    Article  PubMed  Google Scholar 

  19. Anderson RH, Jacobs ML (2008) The anatomy of tetralogy of Fallot. Cardiol Young 18:1221

    Google Scholar 

  20. Bailliard F, Anderson RH (2009) Tetralogy of Fallot. Orphanet J Rare Diseases 4:2-12

    Article  Google Scholar 

  21. Van Praagh R, Van Praagh S, Nebesar RA et al (1970) Tetralogy of Fallot: underdevelopment of the pulmonary infundibulum and its sequelae. Am J Cardiol 26:25-33

    Article  PubMed  CAS  Google Scholar 

  22. Van Praagh R (1989) Etienne-Louis Arthur Fallot and his tetralogy: a new translation of Fallot's summary and a modern reassessment of this anomaly. Eur J Cardio-thorac Surg 3:381-386

    Article  CAS  Google Scholar 

  23. Howell CE, Ho SY, Anderson RH, Elliott MJ (1990) Variation within the fibrous skeleton and ventricular outflow tracts in tetralogy of Fallot. Ann Thorac Surg 50:450-457

    Article  PubMed  CAS  Google Scholar 

  24. Anderson RH, Becker AE (1990) Etienne-Louis Arthur Fallot and his tetralogy: a new translation of Fallot's summary and a modern reassessment of this anomaly. Letter to Editor. Eur J Cardio-thorac Surg 4:229-230

    Article  CAS  Google Scholar 

  25. Gatzoulis MA, Soukias N, Ho SY, Anderson RH (1990) Echocardiographic and morphological correlation in tetralogy of Fallot. Eur Heart J 20:221-231

    Article  Google Scholar 

  26. Friedman BA, Hlavacek A, Chessa K et al (2010) Clinico-morphological correlations in the categorization of holes between the ventricles. Ann Ped Cardiol 3:12-24

    Article  Google Scholar 

  27. Dickinson DF, Wilkinson JL, Smith A et al (1982) Variations in the morphology of the ventricular septal defect and disposition of the atrioventricular conduction tissues in tetralogy of Fallot. Thorac Cardiovasc Surg 30:243-249

    Article  PubMed  CAS  Google Scholar 

  28. Thiene G, Mazzucco A, Anderson RHet al (1984) Tetralogy of Fallot after surgery: autopsy review of 14 cases. Human Pathol 15:995-1018

    Article  Google Scholar 

  29. Griffin ML, Sullivan ID, Anderson RH, McCartney FJ (1988) Doubly committed subarterial ventricular septal defect: new morphological criteria with ecocardiographic and angiographic correlation. Br Heart J 59:474-479

    Article  PubMed  CAS  Google Scholar 

  30. Thiene G, Bortolotti U, Gallucci V et al (1977) Pulmonary atresia with ventricular septal defect. Br Heart J 39: 1233–1240

    Article  Google Scholar 

  31. Thiene G, Frescura C, Bini RM et al (1981) Histology of pulmonary arterial supply in pulmonary atresia with ventricular septal defect. Br Heart J 60:1066-1074

    Google Scholar 

  32. Anderson RH, Devine WA, Del Nido P (1991) The surgical anatomy of tetralogy of Fallot with pulmonary atresia rather than pulmonary stenosis. J Cardiac Surg 6:41-58

    Article  CAS  Google Scholar 

  33. Ho YS, Catani A, Seo JW (1992) Arterial supply to the lungs in tetralogy of Fallot with pulmonary atresia or critical pulmonary stenosis. Cardiol Young 2:65-72

    Google Scholar 

  34. Thiene G, Frescura C, Di Donato R, Gallucci V (1979) Complete atrioventricular canal with conotruncal malformations: anatomical observations in 13 specimens. Europ J Cardiol 9:199-213

    CAS  Google Scholar 

  35. Bharati S, Kirklin JW, McAllister HA, Lev M (1980) The surgical anatomy of common atrioventricular orifice associated with tetralogy of Fallot, double outlet right ventricle and complete regular transposition. Circulation 61:1142-1149

    Article  PubMed  CAS  Google Scholar 

  36. Ricci M, Tchervenkov CI, Jacobs JP et al (2008) Surgical correction for patients with tetralogy of Fallot and common atrioventricular junction. Cardiol Young 18:29-38

    Article  PubMed  Google Scholar 

  37. Faggian G, Frescura C, Thiene G et al (1983) Accessory tricuspid valve tissue causing obstruction of the ventricular septal defect in tetralogy of Fallot. Br Heart J 49:318-324

    Article  Google Scholar 

  38. Suzuki A, Ho YS, Anderson RH, Deanfield JE (1990) Further morphologic studies on tetralogy of Fallot with particular emphasis on the prevalence and structure of the membranous flap. J Thorac Cardiovasc Surg 99:528-535

    PubMed  CAS  Google Scholar 

  39. Kurosawa H, Morita K, Yamagishi M et al (1998) Conotruncal repair for tetralogy of Fallot: midterm results. J Thorac Cardiovasc Surg 115:351-360

    Article  PubMed  CAS  Google Scholar 

  40. Emmanouilides GC, Thanopoulos B, Siassi B, Fishbein M (1976) “Agenesis” of ductus arteriosus associated with the syndrome of tetralogy of Fallot and absent pulmonary valve. Am J Cardiol 37:403-409

    Article  Google Scholar 

  41. Rabinovitch M, Grady S, David I et al (1982) Compression of intrapulmonary bronchi by abnormally branching pulmonary arteries associated with absent pulmonary valve. Am J Cardiol 50:804-813

    Article  PubMed  CAS  Google Scholar 

  42. Milanesi O, Talenti E, Pellegrino PA, Thiene G (1984) Abnormal pulmonary artery branching in tetralogy of Fallot with absent pulmonary valve. Int J Cardiol 6:375-380

    Article  PubMed  CAS  Google Scholar 

  43. Velasquez G, Nath PH, Castaneda-Zuniga WR et al (1980) Aberrant left subclavian artery in tetralogy of Fallot. Am J Cardiol 45:811-818

    Article  PubMed  CAS  Google Scholar 

  44. Tan JL, Gatzoulis MA, Ho SY (2006) Aortic root disease in tetralogy of Fallot. Current opinion in Cardiology 2:569-572

    Article  Google Scholar 

  45. Li J, Soukias ND, Carvalho JS, Ho SY (1988) Coronary arterial anatomy in tetralogy of Fallot: morphological and clinical correlation. Heart 80:74-183

    Google Scholar 

  46. Marino B, Digilio MC, Grazioli S et al (1996) Associated cardiac anomalies in isolated and syndromic patients with tetralogy of Fallot. Am J Cardiol 77:505-508

    Article  PubMed  CAS  Google Scholar 

  47. Momma K (2010) Cardiovascular anomalies associated with chromosome 22q11.2 deletion syndrome. Am J Cardiol 105:1617-1624

    Article  PubMed  CAS  Google Scholar 

  48. Kirklin JW, Blackstone EH, Kirklin JW et al (1981) Intracardiac surgery in infants under age 3 months: incremental risk factors for hospital mortality. Am J Cardiol 48:500-505

    Article  PubMed  CAS  Google Scholar 

  49. Lurz P, Bonhoeffer P, Taylor AM (2009) Percutaneous pulmonary valve implantation. An update. Expert Rev Cardiovasc Ther 7:823-833

    Article  PubMed  Google Scholar 

  50. Kirklin JW, McGoon DC, DuShane JW (1960) Surgical treatment of ventricular septal defect. J Thorac Cardiovasc Surg 40:763-770

    PubMed  CAS  Google Scholar 

  51. Puga FJ, Leoni FE, Julsrud PR, Mair DD (1989) Complete repair of pulmonary atresia, ventricular septal defect and severe peripheral arborization abnormalities of the central pulmonary arteries: experience with preliminary unifocalazation procedures in 38 patients. J Thorac Cardiovasc Surg 98:1018-1029

    PubMed  CAS  Google Scholar 

  52. Iyer KS, Mee RBB (1991) Staged repair of pulmonary atresia with ventricular septal defect and major systemic to pulmonary artery collaterals. Ann Thorac Cardiovasc Surg 51:62-72

    Google Scholar 

  53. Reddy MV, Liddicoat JR, Hanley FL (1995) Mid line one-stage complete unifocalization and repair of pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals. J Thorac Cardiovasc Surg 109:832-845

    Article  PubMed  CAS  Google Scholar 

  54. Basso C, Frescura C, Corrado D et al (1995) Congenital heart disease and sudden death in the young. Human Pathol 26:1065-1072

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy

    Carla Frescura

Authors
  1. Carla Frescura
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  2. Gaetano Thiene
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Editors and Affiliations

  1. Pediatric and Adult Congenital Heart Center, IRCCS Policlinico San Donato, San Donato Milanese (Mi), Italy

    Massimo Chessa

  2. Cardio-Thoracic Surgery, IRCCS Policlinico San Donato, San Donato Milanese (Mi), Italy

    Alessandro Giamberti

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Frescura, C., Thiene, G. (2012). Anatomy of Tetralogy of Fallot. In: Chessa, M., Giamberti, A. (eds) The Right Ventricle in Adults with Tetralogy of Fallot. Springer, Milano. https://doi.org/10.1007/978-88-470-2358-1_2

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  • DOI: https://doi.org/10.1007/978-88-470-2358-1_2

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2357-4

  • Online ISBN: 978-88-470-2358-1

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