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Terapia delle malattie neurologiche pp 101–129Cite as

Sclerosi multipla e varianti

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Riassunto

L’eziologia della sclerosi multipla (SM) rimane largamente sconosciuta, ma negli ultimi anni, grazie all’impressionante sviluppo della genetica, si sono fatti progressi importanti, anche se probabilmente solo iniziali, nell’individuazione dei fattori genetici che regolano l’esposizione alla malattia [1]. Un aspetto rilevante sta emergendo: il fenotipo sclerosi multipla è sicuramente il risultato di un’intricata interazione di disfunzioni interessanti diverse vie metaboliche ed immunitarie, per cui è lecito attendersi una certa variabilitá interindividuale della risposta a specifiche terapie. La risposta sará maggiore quando il target dell’intervento è molto selettivo come nelle vaccinazioni, mentre sará minore quando il bersaglio è una via ultima comune, come ad esempio la penetrazione della barriera ematoencefalica.

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    Giancarlo Comi & Lucia Moiola

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Comi, G., Moiola, L. (2009). Sclerosi multipla e varianti. In: Terapia delle malattie neurologiche. Springer, Milano. https://doi.org/10.1007/978-88-470-1120-5_8

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