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TGF-β Receptors and Signal Transduction

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Book cover Bone Marrow Transplantation

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Summary

Transforming growth factor-β (TGF-β) is a family of 25-kDa dimeric proteins that regulate the cellular growth and differentiation, the formation of extracellular matrix, and the immune function. TGF-βs belong to a larger family of structurally related proteins known as the TGF-β superfamily, which includes activins and bone morphogenetic proteins. TGF-β exerts the effects through binding to type I (TβR-I; 53 kDa) and type II (TβR-II; 75 kDa) serine/threonine kinase receptors. Overall structures of TβR-I and TβR-II are similar to each other. Preceding the kinase domain of TβR-I, there is a region termed the GS domain, which is conserved in type I receptors, but not in type II receptors. After ligand binding, TβR-I and TβR-II form a heteromeric receptor complex, which is most likely a heterotetramer composed of two molecules each of TβR-I and TβR-II. TβR-II transphosphorylates the GS domain of TβR-I, which then activates the TβR-I kinase and transduces signals. By yeast two-hybrid system, several proteins which interact with type I or type II receptors, and possibly transduce the signals for TGF-p, have been isolated. Mutations in the TβR-II gene have been identified in several carcinoma cells, which suggests that loss of the TβR-II protein is one of the mechanisms by which cancer cells acquire resistance to the growth inhibitory activity of TGF-β.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, The Cancer Institute, Tokyo, Japan

    Kohei Miyazono

  2. Japanese Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170, Japan

    Kohei Miyazono

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  1. Kohei Miyazono
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Editors and Affiliations

  1. First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570, Japan

    Susumu Ikehara M.D., Ph.D. (Professor) (Professor)

  2. International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162, Japan

    Fumimaro Takaku M.D., Ph.D. (President) (President)

  3. Department of Pediatrics, All Children’s Hospital, University of South Florida, 801 Sixth Street South, Box 753, St. Petersburg, FL, 33701, USA

    Robert A. Good M.D., Ph.D., D.Sc., FACP (Distinguished Research Professor, University of South Florida, Head of Allergy and Clinical Immunology) (Distinguished Research Professor, University of South Florida, Head of Allergy and Clinical Immunology)

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© 1996 Springer-Verlag Tokyo

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Miyazono, K. (1996). TGF-β Receptors and Signal Transduction. In: Ikehara, S., Takaku, F., Good, R.A. (eds) Bone Marrow Transplantation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68320-9_15

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  • DOI: https://doi.org/10.1007/978-4-431-68320-9_15

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68322-3

  • Online ISBN: 978-4-431-68320-9

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