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Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers

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Pathogenesis of Idiopathic Scoliosis

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Abstract

Idiopathic scoliosis (IS) is a condition where the spinal curve is deformed. IS appears at the onset of puberty and is most often seen in women. Current literature reveals potential biomarkers of the onset and progression of IS, which include hormones, systemic factors, hematological factors, and bone metabolism factors. Hormones that include growth hormone, melatonin, estrogen, ghrelin, and leptin, systemic factors, such as osteopontin and Gi proteins; proteins involved in bone metabolism, such as matrilin-1, cartilage oligomeric matrix protein and osteocalcin; and the hematological protein calmodulin, have been implicated as potential diagnostic biomarkers in IS. Most of these biochemical factors are interconnected through signaling pathways. In this chapter we discuss the validity of published studies and the contradictory data for each factor. We will also elaborate on the hypotheses associated with these factors and their potential relevance in the pathogenesis of IS.

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Acknowledgment

The authors would like to thank Dr. Smitha S. Dutt and Ms. Anita Franco for their critical review, writing assistance, and technical editing of this book chapter. This work was supported in part by a research grant from the Yves Cotrel Foundation (Institut de France, Paris). Mrs. Dina Nada was the recipient of CHU Sainte-Justine Foundation Scholarship.

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Authors and Affiliations

  1. Viscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Sainte-Justine University Hospital Research Center, Montreal, QC, Canada

    Dina Nada M.Sc & Alain Moreau Ph.D.

  2. Faculty of Medicine, Department of Biomedical Sciences, Université de Montréal, Montreal, QC, Canada

    Dina Nada M.Sc & Alain Moreau Ph.D.

  3. Faculty of Dentistry, Department of Stomatology, Université de Montréal, Montreal, QC, Canada

    Alain Moreau Ph.D.

  4. Faculty of Medicine, Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada

    Alain Moreau Ph.D.

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  1. Dina Nada M.Sc
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Correspondence to Alain Moreau Ph.D. .

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  1. Department of Spine and Spinal Cord Surgery, Yokohama Brain and Spine Center, Yokohama, Kanagawa, Japan

    Masafumi Machida

  2. University of Iowa, Iowa, USA

    Stuart L. Weinstein

  3. Academie Nationale de Medecine, Paris, France

    Jean Dubousset

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Nada, D., Moreau, A. (2018). Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers. In: Machida, M., Weinstein, S., Dubousset, J. (eds) Pathogenesis of Idiopathic Scoliosis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56541-3_5

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