Skip to main content
Book cover

Osteosarcoma pp 125–133Cite as

Limb-Salvage Surgery and Reconstruction for Skeletally Immature Childhood Osteosarcoma: Extendible Endoprosthesis

  • Chapter
  • First Online:
  • 1358 Accesses

Abstract

The purpose of this article is to report on the development, indication, and clinical outcome of extendible endoprostheses for the management of osteosarcomas in the skeletally immature patients after resection of major growth plates in conjunction with limb-salvage surgery. The first generation of extendible endoprostheses appeared in the late 1970s. They were invasive, and open lengthening procedures were required. Several subsequent modifications have yielded the endoprostheses capable of lengthening through less invasive methods to minimize the risk of complications. An extendible endoprosthesis should be applied for the skeletally immature patients when the estimated leg length discrepancy at skeletal maturity is expected to be more than 3 cm or when the arm length discrepancy will be more than 5 cm. Prosthetic reconstruction is well received emotionally and cosmetically. Furthermore, even if additional revision surgeries are required, extendible endoprostheses provide good functional outcome in skeletally immature children with osteosarcomas. However, the patients and their families must be carefully selected with an emphasis on motivation and acceptance, since rather frequent and substantial treatment during follow-up is inevitably required. In the future, improvements in the surgical techniques and endoprosthetic designs are needed to diminish the number of complications.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Simon MA, Aschliman MA, Thomas N, Mankin HJ. Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am. 1986;68:1331–7.

    CAS  PubMed  Google Scholar 

  2. Rougraff BT, Simon MA, Kneisl JS, Greenberg DB, Mankin HJ. Limb salvage compared with amputation for osteosarcoma of the distal end of the femur. A long-term oncological, functional, and quality-of-life study. J Bone Joint Surg Am. 1994;76:649–56.

    CAS  PubMed  Google Scholar 

  3. Link MP, Goorin AM, Horowitz M, Meyer WH, Belasco J, Baker A, Ayala A, Shuster J. Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study. Clin Orthop. 1991;270:8–14.

    PubMed  Google Scholar 

  4. Schiller C, Windhager R, Fellinger EJ, Salzer-Kuntschik M, Kaider A, Kotz R. Extendable tumour endoprostheses for the leg in children. J Bone Joint Surg (Br). 1995;77:608–14.

    CAS  Google Scholar 

  5. Bacci G, Picci P, Ferrari S, Ruggieri P, Casadei R, Tienghi A, Brach el Prever A, Gherlinzoni F, Mercuri M, Monti C. Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities. Results in 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin. Cancer. 1993;72:3227–38.

    Article  CAS  PubMed  Google Scholar 

  6. Futani H, Minamizaki T, Nishimoto Y, Abe S, Yabe H, Ueda T. Long-term follow-up after limb salvage in skeletally immature children with a primary malignant tumor of the distal end of the femur. J Bone Joint Surg Am. 2006;88:595–603.

    Article  PubMed  Google Scholar 

  7. Gross RH. Leg length discrepancy: how much is too much? Orthopedics. 1978;1:307–10.

    CAS  PubMed  Google Scholar 

  8. Gonzalez-Herranz P, Burgos-Flores J, Ocete-Guzman JG, Lopez-Mondejar JA, Amaya S. The management of limb-length discrepancies in children after treatment of osteosarcoma and Ewing’s sarcoma. J Pediatr Orthop. 1995;15:561–5.

    Article  CAS  PubMed  Google Scholar 

  9. Tsuchiya H, Abdel-Wanis ME, Sakurakichi K, Yamashiro T, Tomita K. Osteosarcoma around the knee. Intraepiphyseal excision and biological reconstruction with distraction osteogenesis. J Bone Joint Surg (Br). 2002;84:1162–6.

    Article  CAS  Google Scholar 

  10. Erler K, Yildiz C, Baykal B, Atesalp AS, Ozdemir MT, Basbozkurt M. Reconstruction of defects following bone tumor resections by distraction osteogenesis. Arch Orthop Trauma Surg. 2005;125:177–83.

    Article  PubMed  Google Scholar 

  11. Brigman BE, Hornicek FJ, Gebhardt MC, Mankin HJ. Allografts about the knee in young patients with high-grade sarcoma. Clin Orthop Relat Res. 2004;421:232–9.

    Article  PubMed  Google Scholar 

  12. Campanacci L, Manfrini M, Colangeli M, Alí N, Mercuri M. Long-term results in children with massive bone osteoarticular allografts of the knee for high-grade osteosarcoma. J Pediatr Orthop. 2010;30:919–27.

    Article  PubMed  Google Scholar 

  13. Stanitski DF. Limb-length inequality: assessment and treatment options. J Am Acad Orthop Surg. 1999;7:143–53.

    CAS  PubMed  Google Scholar 

  14. Marulanda GA, Henderson ER, Palumbo BT, Alexander GE, Cheong D, Letson GD. Use of extendable prostheses: a limb-salvaging alternative for patients with malignant bone tumors. Expert Rev Med Devices. 2008;5:467–74.

    Article  PubMed  Google Scholar 

  15. Unwin PS, Walker PS. Extendible endoprostheses for the skeletally immature. Clin Orthop. 1996;322:179–93.

    Article  PubMed  Google Scholar 

  16. Lewis MM, Bloom N, Esquieres EM, Kenan S, Ryniker DM. The expandable prosthesis. An alternative to amputation for children with malignant bone tumors. AORN J. 1987;46:457–70.

    Article  CAS  PubMed  Google Scholar 

  17. Neel MD, Wilkins RM, Rao BN, Kelly CM. Early multicenter experience with a noninvasive expandable prosthesis. Clin Orthop Relat Res. 2003;415:72–81.

    Article  PubMed  Google Scholar 

  18. Wilkins RM, Miller CM. Reoperation after limb preservation surgery for sarcomas of the knee in children. Clin Orthop. 2003;412:153–61.

    Article  PubMed  Google Scholar 

  19. Wilkins RM, Soubeiran A. The Phenix expandable prosthesis: early American experience. Clin Orthop Relat Res. 2001;382:51–8.

    Article  PubMed  Google Scholar 

  20. O’Flanagan SJ, Stack JP, McGee HM, Dervan P, Hurson B. Imaging of intramedullary tumour spread in osteosarcoma. A comparison of techniques. J Bone Joint Surg (Br). 1991;73:998–1001.

    Google Scholar 

  21. Finn HA, Simon MA. Limb-salvage surgery in the treatment of osteosarcoma in skeletally immature individuals. Clin Orthop. 1991;262:108–18.

    PubMed  Google Scholar 

  22. Anderson M, Green WT, Messner MB. Growth and predictions of growth in the lower extremities. J Bone Joint Surg Am. 1963;45:1–14.

    PubMed  Google Scholar 

  23. Westh RN, Menelaus MB. A simple calculation for the timing of epiphysial arrest. A further report. J Bone Joint Surg (Br). 1981;63:117–9.

    Google Scholar 

  24. Cool WP, Carter SR, Grimer RJ, Tillman RM, Walker PS. Growth after extendible endoprosthetic replacement of the distal femur. J Bone Joint Surg (Br). 1997;79:938–42.

    Article  CAS  Google Scholar 

  25. Pritchett JW. Longitudinal growth and growth-plate activity in the lower extremity. Clin Orthop Relat Res. 1992;275:274–9.

    PubMed  Google Scholar 

  26. Song KM, Halliday SE, Little DG. The effect of limb length on gait. J Bone Joint Surg Am. 1997;79:1690–8.

    Article  CAS  PubMed  Google Scholar 

  27. Kenan S, Lewis MM. Limb salvage in pediatric surgery. The use of the expandable prosthesis. Orthop Clin North Am. 1991;22:121–31.

    CAS  PubMed  Google Scholar 

  28. Ayoub KS, Fiorenza F, Grimer RJ, Tillman RM, Carter SR. Extensible endoprostheses of the humerus after resection of bone tumours. J Bone Joint Surg (Br). 1999;81:495–500.

    Article  CAS  Google Scholar 

  29. Greulich WW, Pyle SI. Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Stanford: Stanford University Press; 1966.

    Google Scholar 

  30. Dominkus M, Krepler P, Schwameis E, Windhager R, Kotz R. Growth prediction in extendable tumor prostheses in children. Clin Orthop Relat Res. 2001;390:212–20.

    Article  PubMed  Google Scholar 

  31. Delepine G, Delepine N, Desbois JC, Goutallier D. Expanding prostheses in conservative surgery for lower limb sarcoma. Int Orthop. 1998;22:27–31.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  32. Eckardt JJ, Kabo JM, Kelley CM, Ward Sr WG, Asavamongkolkul A, Wirganowicz PZ, Yang RS, Eilber FR. Expandable endoprosthesis reconstruction in skeletally immature patients with tumors. Clin Orthop. 2000;373:51–61.

    Article  PubMed  Google Scholar 

  33. Grimer RJ, Belthur M, Carter SR, Tillman RM, Cool P. Extendible replacements of the proximal tibia for bone tumours. J Bone Joint Surg (Br). 2000;82:255–60.

    Article  CAS  Google Scholar 

  34. Schindler OS, Cannon SR, Briggs TW, Blunn GW. Stanmore custom-made extendible distal femoral replacements. J Bone Joint Surg (Br). 1997;79:927–37.

    Article  CAS  Google Scholar 

  35. Ruggieri P, Mavrogenis AF, Pala E, Romantini M, Manfrini M, Mercuri M. Outcome of expandable prostheses in children. J Pediatr Orthop. 2013;33:244–53.

    Article  PubMed  Google Scholar 

  36. Daltroy LH, Liang MH, Fossel AH, Goldberg MJ. The POSNA pediatric musculoskeletal functional health questionnaire: report on reliability, validity, and sensitivity to change. Pediatric Outcomes Instrument Development Group. Pediatric Orthopaedic Society of North America. J Pediatr Orthop. 1998;18:561–71.

    Article  CAS  PubMed  Google Scholar 

  37. Henderson ER, Pepper AM, Marulanda GA, Millard JD, Letson GD. What is the emotional acceptance after limb salvage with an expandable prosthesis? Clin Orthop Relat Res. 2010;468:2933–8.

    Article  PubMed Central  PubMed  Google Scholar 

  38. Cara JA, Canadell J. Limb salvage for malignant bone tumors in young children. J Pediatr Orthop. 1994;14:112–8.

    Article  CAS  PubMed  Google Scholar 

  39. Alman BA, De Bari A, Krajbich JI. Massive allografts in the treatment of osteosarcoma and Ewing sarcoma in children and adolescents. J Bone Joint Surg Am. 1995;77:54–64.

    CAS  PubMed  Google Scholar 

  40. Picardo NE, Blunn GW, Shekkeris AS, Meswania J, Aston WJ, Pollock RC, Skinner JA, Cannon SR, Briggs TW. The medium-term results of the Stanmore non-invasive extendible endoprosthesis in the treatment of paediatric bone tumours. J Bone Joint Surg (Br). 2012;94:425–30.

    Article  CAS  Google Scholar 

  41. Neel MD, Letson GD. Modular endoprostheses for children with malignant bone tumors. Cancer Control. 2001;8:344–8.

    CAS  PubMed  Google Scholar 

  42. Cannon SR. Massive prostheses for malignant bone tumours of the limbs. J Bone Joint Surg (Br). 1997;79:497–506.

    Article  CAS  Google Scholar 

  43. Gosheger G, Hardes J, Ahrens H, Streitburger A, Buerger H, Erren M, Gunsel A, Kemper FH, Winkelmann W, Von Eiff C. Silver-coated megaendoprostheses in a rabbit model – an analysis of the infection rate and toxicological side effects. Biomaterials. 2004;25:5547–56.

    Article  CAS  PubMed  Google Scholar 

  44. Shirai T, Tsuchiya H, Nishida H, Yamamoto N, Watanabe K, Nakase J, Terauchi R, Arai Y, Fujiwara H, Kubo T. Antimicrobial megaprostheses supported with iodine. J Biomater Appl. 2014;29:617–23.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hiroyuki Futani .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Japan

About this chapter

Cite this chapter

Futani, H., Yoshiya, S. (2016). Limb-Salvage Surgery and Reconstruction for Skeletally Immature Childhood Osteosarcoma: Extendible Endoprosthesis. In: Ueda, T., Kawai, A. (eds) Osteosarcoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55696-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-55696-1_10

  • Published:

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55695-4

  • Online ISBN: 978-4-431-55696-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics