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Lymphocyte Homing and Trafficking

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Compendium of Inflammatory Diseases

Synonyms

Lymphocyte migration

Definition

Lymphocytes are central effector cells of adaptive immune responses. Their ability to migrate from one place to another is a major feature of their action since the initiation of immune responses is centralized in secondary lymphoid organs while the effector phase takes place where needed in peripheral tissues. Here the mechanisms responsible for this ability and major trafficking pathways of lymphocyte in normal and pathological conditions will be discussed.

Structure and Functions

Molecular Basis of Lymphocyte Trafficking

Lymphocyte homing and trafficking are essential functions of adaptive immune responses. The basic molecular processes involved in trafficking are chemotaxis and cellular adhesion. Chemotaxis is mediated mainly by chemokines and inflammatory response by-products (anaphylatoxins and prostaglandins), while cellular adhesion is mediated by selectins interacting with sugars (weak interactions) and integrins (strong interactions).

Chemotaxis...

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Author information

Authors and Affiliations

  1. INSERM UMRS 996, Universté Paris Sud, Chatenay-Malabry, France

    Luc de Chaisemartin

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  1. Luc de Chaisemartin
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Correspondence to Luc de Chaisemartin .

Editor information

Editors and Affiliations

  1. Fraunhofer IME-TMP & JW Goethe University Frankfurt, Frankfurt am Main, Germany

    Michael J. Parnham

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© 2016 Springer International Publishing AG

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de Chaisemartin, L. (2016). Lymphocyte Homing and Trafficking. In: Parnham, M.J. (eds) Compendium of Inflammatory Diseases. Springer, Basel. https://doi.org/10.1007/978-3-7643-8550-7_130

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