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Do N-methyl-D-aspartate Antagonists Have Disproportionately Greater Effects on Brain Swelling than on Ischemic Damage in Focal Cerebral Infarction?

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Brain Edema IX

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 60))

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Summary

Using a frozen section technique, we have assessed the effects of N-methyl-D-aspartate(NMDA) antagonist upon brain swelling caused by ischemic brain edema in a rat model of focal cerebral infarction. Although pretreatment with the competitive NMDA antagonist, D-CPPene or the noncompetitive NMDA antagonist, CNS 1102 reduced both the volumes of infarction and ischemic edema in the cerebral hemisphere, mean reduction in brain edema was proportionately similar to decrease in infarct volume in the same animals (correlation coefficienct, r = 0.82, p < 0.001). There was, therefore, no evidence of disproportionately greater effects with NMDA antagonist upon brain edema.

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Authors and Affiliations

  1. Department of Neurosurgery, Catholic University Medical College, Seoul, Korea

    C. K. Park M.D., J. McCulloch, D. S. Jung, J. K. Kang & C. R. Choi

Authors
  1. C. K. Park M.D.
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  2. J. McCulloch
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  3. D. S. Jung
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  4. J. K. Kang
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  5. C. R. Choi
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red-Cross Hospital, Tokyo, Japan

    Umeo Ito M.D. (Director and Neurosurgeon in Chief) (Director and Neurosurgeon in Chief)

  2. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann M.D. (Professor) (Professor)

  3. Max-Planck Institut für Neurologische Forschung, Köln, Federal Republic of Germany

    Konstantin-A. Hossmann M.D. (Professor) (Professor)

  4. Department of Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D. (Associate Professor) (Associate Professor)

  5. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  6. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Hans-J. Reulen M.D. (Professor) (Professor)

  7. Department of Neurosurgery, Tokyo Women’s Medical College, Tokyo, Japan

    Kintomo Takakura M.D. (Professor) (Professor)

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© 1994 Springer-Verlag

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Park, C.K., McCulloch, J., Jung, D.S., Kang, J.K., Choi, C.R. (1994). Do N-methyl-D-aspartate Antagonists Have Disproportionately Greater Effects on Brain Swelling than on Ischemic Damage in Focal Cerebral Infarction?. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_74

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  • DOI: https://doi.org/10.1007/978-3-7091-9334-1_74

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9336-5

  • Online ISBN: 978-3-7091-9334-1

  • eBook Packages: Springer Book Archive

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