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Cerebral Oedema Following Intracerebral Haemorrhage: the Effect of the NMDA Receptor Antagonists MK-801 and D-CPPene

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Brain Edema IX

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 60))

  • 197 Accesses

Summary

The effects of pre-treatment with the NMDA receptor antagonists MK-801 and D-CPPene on the development of brain oedema were investigated in a rodent model of intracerebral haemorrhage. In acute experiments (4 hour survival) both drugs caused significant hypotension and had significant anaesthetic effects whilst conferring no protection against oedema formation. In chronic experiments (24 hour survival) MK-801 conferred no protection against brain oedema. With D-CPPene marginal protection against cortical oedema may have been conferred but this result should be interpreted with caution.

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References

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Author information

Authors and Affiliations

  1. Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne, England, UK

    I. R. Chambers

  2. Department of Surgery (Neurosurgery), University of Newcastle upon Tyne, England, UK

    Mr. P. J. Kane, S. Cook, I. R. Chambers & A. D. Mendelow

Authors
  1. Mr. P. J. Kane
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  2. S. Cook
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  3. I. R. Chambers
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  4. A. D. Mendelow
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red-Cross Hospital, Tokyo, Japan

    Umeo Ito M.D. (Director and Neurosurgeon in Chief) (Director and Neurosurgeon in Chief)

  2. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann M.D. (Professor) (Professor)

  3. Max-Planck Institut für Neurologische Forschung, Köln, Federal Republic of Germany

    Konstantin-A. Hossmann M.D. (Professor) (Professor)

  4. Department of Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D. (Associate Professor) (Associate Professor)

  5. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  6. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Hans-J. Reulen M.D. (Professor) (Professor)

  7. Department of Neurosurgery, Tokyo Women’s Medical College, Tokyo, Japan

    Kintomo Takakura M.D. (Professor) (Professor)

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© 1994 Springer-Verlag

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Kane, P.J., Cook, S., Chambers, I.R., Mendelow, A.D. (1994). Cerebral Oedema Following Intracerebral Haemorrhage: the Effect of the NMDA Receptor Antagonists MK-801 and D-CPPene. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_155

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  • DOI: https://doi.org/10.1007/978-3-7091-9334-1_155

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9336-5

  • Online ISBN: 978-3-7091-9334-1

  • eBook Packages: Springer Book Archive

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