Summary
2-Propyl-1-aminopentane (2-PAP) and N-(2-propylpentyl)glycinamide (PPG) were readily deaminated by rat liver monoamine oxidase B and rat aorta semicarbazide-sensitive amine oxidase. The deaminated product, valproic acid (VPA), was identified by HPLC-fluorometric assessment. Absorption and biotransformation of these compounds and their VPA metabolite into the brain were rapid processes. An investigation was conducted to examine whether these compounds can be used as VPA prodrugs. Both compounds, however, at relatively low doses exhibited distinct tremor effects in mice and rats. They also potentiate the convulsant effect induced by mercaptopropionic acid (MPA).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Blaschko H (1981) Amine oxidase and amine metabolism. Pharmacol Rev 4:414–458.
De Varebeke PJ, Cavalier R, David-Remacle M, Youdim MBH (1988) Formation of the neurotransmitter glycine from the anticonvulsant milacemide is mediated by brain monoamine oxidase-B. J Neurochem 50:1011–1016.
Dunges W (1977) 4-Bromomethyl-7-methoxycoumarin as a new fluorescence label for fatty acids. Anal Chem 49:442–444.
Yu PH (1986) Monoamine oxidase. In: Boulton AA, Baker GB, Yu PH (eds) Neuromethods, vol 5. Humana, Clifton NJ, pp 235–272.
Yu PH (1989) Deamination of aliphatic amines of different chain lengths by rat liver monoamine oxidase A and B. J Pharm Pharmacol 41:205–208.
Yu PH (1990) Oxidative deamination of aliphatic amines by rat aorta semi-carbazide-sensitive amine oxidase. J Pharm Pharmacol (in press) Yu PH, Boulton AA (1980) Regional oxidation of tyramine isomers in rat brain. J Neurochem 35:255–257.
Yu PH, Hertz L (1982) Differential development of type A and type B monoamine oxidase of mouse astrocytes in primary cultures. J Neurochem 39:1492–1495.
Yu PH, Davis BA (1988) Stereospecific deamination of benzylamine catalyzed by different amine oxidases. Int J Biochem 20:1197–1201.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag
About this paper
Cite this paper
Yu, P.H., Davis, B.A. (1990). Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-Propyl-1-aminopentane and N-(2-propylpentyl)glycinamide as valproic acid precursors. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_11
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9113-2_11
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82239-5
Online ISBN: 978-3-7091-9113-2
eBook Packages: Springer Book Archive