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Steroids Decrease Uptake of Carboplatin in Rat Gliomas — Uptake Improved by Intracarotid Infusion of Bradykinin Analog, RMP-7

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Brain Edema X

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 70))

Summary

This study sought to determine whether dexamethasone (DXN) treatment of rats with intracranial gliomas would 1) further impair delivery of carboplatin to brain tumors, and 2) whether intracarotid infusion of the bradykinin analog, RMP-7, would improve delivery during concurrent DXN treatment. In DXN pretreated animals, 3 mg/kg/day of DXN was administered intraperitoneally for 3 days prior to Ki determinations. Ki of [14C] carboplatin into DXN-treated tumors and brain surrounding tumor (BST) was significantly lower compared to non-DXN treated tumors and BST (3.30 ± 0.91 vs. 4.47 ± 1.80, p < 0.05, and 0.94 ± 0.84 vs. 2.18 ± 0.79, p < 0.05, respectively). Intracarotid infusion of RMP-7 significantly increased the Ki for carboplatin in DXN-treated tumors (6.35 ±3.10 vs. 3.30 ± 0.91, p < 0.01), however, RMP-7 increased Ki to a greater extent in tumors not pretreated with DXN (12.07 ± 3.60 vs. 4.47 ± 1.80, p < 0.0001). Dexamethasone decreases transport of carboplatin into brain tumors. Intracarotid infusion of RMP-7 selectively increases carboplatin transport to tumors.

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Author information

Authors and Affiliations

  1. Division of Neurosurgery, 17-382 NPI, UCLA Medical Center, Los Angeles, CA, 90095-7039, USA

    K. Matsukado, S. Nakano & Keith L. Black M.D.

  2. Alkermes, Inc., 64 Sidney Street, Cambridge, MA, USA

    R. T. Bartus

Authors
  1. K. Matsukado
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  2. S. Nakano
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  3. R. T. Bartus
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  4. Keith L. Black M.D.
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Editor information

Editors and Affiliations

  1. Pediatric Neurosurgery, San Diego, CA, USA

    Hector E. James M.D.

  2. Division of Neurological Surgery, San Diego Medical Center, University of California, San Diego, CA, USA

    Lawrence F. Marshall M.D.

  3. Institut für Neurochirurgie, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Germany

    Hans J. Raulen (Prof. Dr.) (Prof. Dr.)

  4. Institut für Chirurgische Forschung, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Germany

    Alexander Baethmann (Prof. Dr.) (Prof. Dr.)

  5. Neurological Surgery, Virginia Commonwealth University, Richmond, VA, USA

    Anthony Marmarou Ph.D.

  6. Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo, Japan

    Umeo Ito M.D.

  7. Taubmann Health Care Center, The University of Michigan, Ann Arbor, MI, USA

    Julian T. Hoff M.D.

  8. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D.

  9. Department of Neurosurgery Medical Resarch Center, Polish Academy of Sciences, Warsaw, Poland

    Zbigniew Czernicki M.D., Ph.D.

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© 1997 Springer-Verlag

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Matsukado, K., Nakano, S., Bartus, R.T., Black, K.L. (1997). Steroids Decrease Uptake of Carboplatin in Rat Gliomas — Uptake Improved by Intracarotid Infusion of Bradykinin Analog, RMP-7. In: James, H.E., et al. Brain Edema X. Acta Neurochirurgica Supplements, vol 70. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6837-0_48

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  • DOI: https://doi.org/10.1007/978-3-7091-6837-0_48

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7418-0

  • Online ISBN: 978-3-7091-6837-0

  • eBook Packages: Springer Book Archive

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