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Protein Sequence–Structure–Function–Network Links Discovered with the ANNOTATOR Software Suite: Application to ELYS/Mel-28

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Computational Medicine

Abstract

While very little genomic sequence is interpretable in terms of biological mechanism directly, the chances are much better for protein-coding genes that can be translated into protein sequences. This review considers the different concepts applicable to sequence analysis and function prediction of globular and non-globular protein segments. The publicly accessible ANNOTATOR software environment integrates most of the reliable protein sequence-based function prediction methods, protein domain databases and pathway, and protein–protein interaction collections developed in academia. As application example, the structural and functional domains of mel-28/ELYS, an important nuclear protein, are delineated and are proposed for experimental follow-up in structural biology and functional studies.

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Notes

  1. 1.

    For a tutorial of the user interface refer to (Ooi et al. 2009)

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  1. Bioinformatics Institute (BII), Singapore, Singapore

    Georg Schneider, Westley Sherman, Durga Kuchibhatla, Hong Sain Ooi, Fernanda L. Sirota, Sebastian Maurer-Stroh & Birgit Eisenhaber

  2. Bioinformatics Institute (BII), 30 Biopolis Street, #07-01 Matrix, Singapore, 13867, Singapore

    Frank Eisenhaber

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  1. Georg Schneider
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  3. Durga Kuchibhatla
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    Zlatko Trajanoski

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Schneider, G. et al. (2012). Protein Sequence–Structure–Function–Network Links Discovered with the ANNOTATOR Software Suite: Application to ELYS/Mel-28. In: Trajanoski, Z. (eds) Computational Medicine. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0947-2_7

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