Abstract
The purpose of this study is to clarify the influence of a novel free radical scavenger edaravone on experimental brain injury. Male Wistar rats were anesthetized with 1–2% halothane. Brain injury was produced using a controlled cortical impact injury device. Experimental rats were divided into 2 groups. In the edaravone group, edaravone (3 mg/kg) was twice administered intravenously for 30 minutes. In the saline group, saline solution was administered in the same way. This administration of edaravone or saline solution made it possible to evaluate the relative effects of edaravone by assessment of free radical reaction and water content. As a result, the level of oxygen free radicals at 50 minutes after brain injury was significantly lower in the edaravone group than in the saline group. The water content in the injured brain at 180 minutes was significantly lower in the edaravone group than in the saline group. Therefore, we propose that edaravone may be effective for treatment in head injury.
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References
Chan PH, Longar S, Fishman A (1984) Oxygen-free radical: potential edema mediators in brain injury. In: Inaba Y, Klatzo, Spatz M (eds) Brain edema. Springer Berlin Heidelberg New York Tokyo, pp 317–323
Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL (1991) A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Meth 39: 253–262
Ikeda Y, Long DM (1990) The molecular basis of brain injury and brain edema: the role of oxygen free radicals. Neurosurgery 27: 1–11
Langfitt TW, Gennarelli TA, Obrist WD, Bruce DA, Zimmerman RA (1982) Prospects for the future in the diagnosis and management of head injury: pathophysiology, brain imaging, and population-based studies. Clin Neurosurg 29: 353–376
Nakamura H, Sekino H (2002) Free radical reactions and effects of edaravone on experimental brain injury. St Marianna Med J 30 (preparation)
Olesen SP (1987) Free oxygen radicals decrease electrical resistance of microvascular endothelium in brain. Acta Physiol Scand 129: 181–187
Utsumi H, Ichikawa K, Takeshita K (1995) In vivo ESR measurements of free radical reactions in living mice. Toxicol Lett 82-83: 561–565
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© 2003 Springer-Verlag Wien
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Nakamura, H. et al. (2003). Effects of edaravone on experimental brain injury in view of free radical reaction. In: Kuroiwa, T., et al. Brain Edema XII. Acta Neurochirurgica Supplements, vol 86. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0651-8_67
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DOI: https://doi.org/10.1007/978-3-7091-0651-8_67
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7220-9
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