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Pharmacological preconditioning in global cerebral ischemia

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Mechanisms of Secondary Brain Damage from Trauma and Ischemia

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 89))

Abstract

Single dose 3-nitropropionic acid (3-NPA) 24 hr before global ischemia improves neuronal survival in both, neocortex and hippocampus (‘chemical preconditioning’). Neuronal survival after transient global ischemia requires new protein synthesis during recovery, especially of those with anti-apoptotic function. Bcl-2-protein is expressed in neurons that survive cerebral ischemia and may parallel the time course of tolerance after ischemic preconditioning. With this study we examined whether differences in bcl-2-protein expression compared to baseline may be involved in the induction of ischemic tolerance using 3-NPA.

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References

  1. Adams JM, Cory S (1998) The bcl-2 protein family: Arbiters of cell survival. Science 281: 1322–1326

    Article  CAS  PubMed  Google Scholar 

  2. Ashkenazi A, Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 1305–1308

    Article  CAS  PubMed  Google Scholar 

  3. Brambrink A, Noga H, Astheimer A, Götz B, Körner I, Heimann A, Kempski O (2001) Bcl-2 protein is upregulated after chemical preconditioning using 3-NPA. In: Maturation phenomenon in cerebral ischemia IV, Springer, Berlin Heidelberg New York Tokyo pp 135–140

    Chapter  Google Scholar 

  4. Brambrink A, Schneider A, Noga H, Astheimer A, Götz B, Körner I, Heimann A, Bach A, Kempski O (2000) Toleranceinducing dose of 3-nitropropionic acid modulates bcl-2 and bax balance in the rat brain: a potential mechanism of chemical preconditioning. J Cereb Blood Flow Metab 20: 1425–1436

    Article  CAS  PubMed  Google Scholar 

  5. Chen J, Graham SH, Nakayama M, Zhu RL, Jin K, Stetler RA, Simon RP (1997) Apoptosis repressor genes bcl-2 and bcl-x-long are expressed in the rat brain following global ischemia. J Cereb Blood Flow Metab 17: 2–10

    Article  CAS  PubMed  Google Scholar 

  6. Christensen T, Bruhn T, Balchen T, Diemer NH (1994) Evidence for formation of hydroxyl radicals during reperfusion after global cerebral ischemia in rats using salicylate trapping and microdialysis. Neurobiol Dis 1: 131–138

    Article  CAS  PubMed  Google Scholar 

  7. Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S. Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE (1997) Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. J Neurosci 17: 6165–6178

    CAS  PubMed Central  PubMed  Google Scholar 

  8. Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, Bredesen DE (1996) Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem 67: 1259–1267

    Article  CAS  PubMed  Google Scholar 

  9. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241–251

    Article  CAS  PubMed  Google Scholar 

  10. Hu S, Sheng WS, Peterson PK, Chao CC (1995) Cytokine modulation of murine microglia cell Superoxide production. Glia 13:45–50

    Article  CAS  PubMed  Google Scholar 

  11. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Örd T, Bredesen DE (1993) Bcl-2 Inhibition of neural death: decreased generation of reactive oxygen species. Science 262: 1274–1277

    Article  CAS  PubMed  Google Scholar 

  12. Kato H, Kogure K, Araki T, Liu X-H, Kato K, Itoyama Y (1995) Immunohistochemical localization of Superoxide dismutase in the hippocampus following ischemia in a gerbil model of ischemic tolerance. J Cereb Blood Flow Metab 15: 60–70

    Article  CAS  PubMed  Google Scholar 

  13. Kinouchi H, Epstein CJ, Mizui T, Carlson E, Chen SF, Chan PH (1991) Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn Superoxide dismutase. Proc Natl Acad Sci USA 88: 11158–11162

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Lauritzen M, Hansen AJ, Kronborg D, Wieloch T (1990) Cortical spreading depression is associated with arachidonic acid accumulation and preservation of energy charge. J Cereb Blood Flow Metab 10: 115–122

    Article  CAS  PubMed  Google Scholar 

  15. Meredith MJ, Cusick CL, Soltaniassab S, Sekhar KS, Lu S, Freemann ML (1998) Expression of bcl-2 increase intracellular glutathione by inhibiting methionine-dependent GSH efflux. Biochem Biophys Res Com 248: 458–463

    Article  CAS  PubMed  Google Scholar 

  16. Moriishi K, Huang DS, Cory S, Adams JM (1999) Bcl-2 famili members do not inhibit apoptosis by binding the caspase activator Apaf-1. Proc Natl Acad Sci USA 96: 9683–9688

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Nakase H, Heimann A, Uranishi R, Riepe MW, Kempski O (2000) Early-onset tolerance to rat global cerebral ischemia induced by a mitochondrial inhibitor. Neurosci Letters 290: 105–108

    Article  CAS  Google Scholar 

  18. Riepe MW, Esclaire F, Kasischke K, Schreiber S, Nakase H, Kempski O, Ludolph AC, Dirnagl U, Hugon J (1997) Increased hypoxic tolerance by chemical inhibition of oxydative phosphorylation: chemical preconditioning. J Cereb Blood Flow Metab 17: 257–264

    Article  CAS  PubMed  Google Scholar 

  19. Siesjö BK, Agardh CD, Bengtsson F (1989) Free radicals and brain damage. Cerebrovasc Brain Metab Rev 1: 165–211

    PubMed  Google Scholar 

  20. Simon RP, Chen J (1996) Apoptosis receptor gene bcl-2; potential role in ischemia tolerance. In: Krieglstein J, Oberpichler-Schwenk H (eds) Pharmacology of cerebral ischemia 1996. Medpharm Scientific Publisher, Stuttgart, pp 25–31

    Google Scholar 

  21. Sugino T, Nozaki K, Tagagi Y, Hashimoto N (1999) 3-Nitropropionic acid induces ischemic tolerance in gerbil hippocampus in vivo. Neurose Lett 259: 9–12

    Article  CAS  Google Scholar 

  22. Toyoda T, Kassell NF, Lee KS (1997) Induction of ischemic tolerance and antioxidant activity by brief focal ischemia. Neuroreport 8: 847–851

    Article  CAS  PubMed  Google Scholar 

  23. Wiegand F, Lindauer U, Busch C, Liao W, Megow D, Dirnagl U (1997) Tolerance to focal ischemia induced by 3-Nitropropionic acid (3-NPA) is mediated by formation of reactive oxygen species (ROS). Soc Neurosci Abstr 23: 2183

    Google Scholar 

  24. Xu DG, Crocker SJ, Doucet JP, St.-Jean M, Tamai K, Hakim AM, Ikeda JE, Liston P, Thompson CS, Kornelik RG, MacKenzie A, Robertson GS (1997) Elevation of neuronal expression of N AIP reduces ischemic damage in the rat hippocampus. Nat Med 3: 997–1004

    Article  CAS  PubMed  Google Scholar 

  25. Zamzami N, Brenner C, Marzo I, Susin SA, Kroemer G (1998) Subcellular and submitochondrial mode of bcl-2-like oncoproteins. Oncogene 16: 2265–2282

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut of Neurosurgical Pathophysiology, Johannes Gutenberg-University, Mainz, Germany

    A. M. Brambrink, H. Noga, A. Astheimer, A. Heimann & Prof. Dr O. Kempski

Authors
  1. A. M. Brambrink
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  2. H. Noga
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  3. A. Astheimer
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  4. A. Heimann
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  5. Prof. Dr O. Kempski
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Editor information

Editors and Affiliations

  1. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität München, München, Germany

    A. Baethmann  & N. Plesnila  & 

  2. Neurochirurgische Klinik, Universität Würzburg, Würzburg, Germany

    J. Eriskat

  3. Neurochirurgische Klinik, Universität Freiburg, Freiburg, Germany

    J. Lehmberg

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© 2004 Springer-Verlag Wien

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Brambrink, A.M., Noga, H., Astheimer, A., Heimann, A., Kempski, O. (2004). Pharmacological preconditioning in global cerebral ischemia. In: Baethmann, A., Eriskat, J., Lehmberg, J., Plesnila, N. (eds) Mechanisms of Secondary Brain Damage from Trauma and Ischemia. Acta Neurochirurgica Supplements, vol 89. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0603-7_8

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  • DOI: https://doi.org/10.1007/978-3-7091-0603-7_8

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7206-3

  • Online ISBN: 978-3-7091-0603-7

  • eBook Packages: Springer Book Archive

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