Abstract
Background: Cerebral vasospasm (CVS) is one of the most considerable complications of subarachnoid hemorrhage (SAH). The aim of this study was to assess and to compare the ability of intrathecal dotarizine and nimodipine to prevent and treat vasospasm in a rabbit model of subarachnoid hemorrhage.
Method: Thirty male New Zealand white rabbits weighing 2,500–3,000 g were allocated into five groups randomly. The treatment groups were as follows: Control, only SAH, SAH/Dotarizine, SAH/Nimodipine, SAH/Vehicle. Forty-eight hours after SAH injection, all animals underwent femoral artery catheterization procedure by open surgery under anesthesia and angiography performed for each animal in the fifth day just before sacrifice.
Findings: Basilar artery vessel diameters are measured by angiography. Basilar artery vessel diameters and luminal sectional areas are measured in pathology slides. There was a statistically significant difference between the mean basilar artery cross-sectional areas and the mean arterial wall thickness measurements of the control and SAH-only groups (p < 0.05).
Conclusions: These findings demonstrate that calcium channel blocker dotarizine has marked vasodilatory effect in an experimental model of SAH in rabbits. Nimodipine is an effect-proven agent in CVS, but dotarizine may take place of it.
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References
Conti A, Angileri FF, Longo M, Pitrone A, Granata F, La Rosa G. Intra-arterial nimodipine to treat symptomatic cerebral vasospasm following traumatic subarachnoid haemorrhage. Technical case report. Acta Neurochir (Wien). 2008;150(11):1197–202.
Dorhout Mees SM, Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M,et al. Calcium antagonists for aneurysmal subarachnoid hemorrhage. Stroke. 2008;39:514.
Firat MM, Gelebek V, Orer HS, Belen D, Firat AK, Balkanci F. Selective intraarterial nimodipine treatment in an experimental subarachnoid hemorrhage model. AJNR. 2005;26(6):1357–62.
Koèniewska E, Michalik R, Rafalowska J, Gadamski R, Walski M, Frontczak-baniewicz M, et al. Mechanisms of vascular dysfunction after subarachnoid hemorrhage. J Physiol Pharmacol. 2006;57 Suppl 11:145.
Komotar RJ, Zacharia BE, Valhora R, Mocco J, Sander Connolly E Jr. Advances in vasospasm treatment and prevention J Neur Sci. 2007;261:134–142.
Kuridze N, Czernickia Z, Dziedzic KJ, Jurkiewicz J, Navarro JC. Regional differences of cerebrovascular reactivity effected by calcium channel blocker Dotarizine J Neuro Sci. 2000;175:13–16.
Mayer TE, Dichgans M, Straube A, Birnbaum T, Müller-Schunk S, Hamann GF, et al. Continuous intra-arterial nimodipine for the treatment of cerebral vasospasm.Cardiovasc Intervent Radiol. 2008;31(6):1200–4.
Olivera BM, Miljanich GP, Ramachandran J, Adams ME. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem. 1994;63:823–67.
Pickard JD, Murray GD, Illingworth R, Shaw MD, Teasdale GM, Foy PM, et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. BMJ. 1989;298:636–42.
Rinkel GJ, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, van Gijn J. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2005;25;(1):CD000277.
Tejerina T, Chulia T, Gonzalez P. Effects of dotarizine on 45Ca2+ movements and contractile responses in vascular smooth muscle. Eur J Pharmacol. 1993;239(1–3):75–81.
Treggiari-Venzi MM, Suter PM, Romand JA. Review of medical prevention of vasospasm after aneurysmal subarachnoid hemorrhage: a problem of neurointensive care. Neurosurgery. 2001;48(2):249–61.
Villarroya M, Gandía L, Lara B, Albillos A, López MG, García AG. Dotarizine versus flunarizine as calcium antagonists in chromaffin cells. Br J Pharmacol. 1995;114(2):369–76.
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Onal, M.B. et al. (2011). Comparison of Intrathecal Dotarizine and Nimodipine Treatments in Cerebral Vasospasm After Subarachnoid Hemorrhage: An Experimental Study in Rabbits. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0356-2_11
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