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Erkrankungen des Nervensystems

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Obladens Neugeborenenintensivmedizin

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Zusammenfassung

Schädigungen des unreifen Gehirns werden zunehmend besser verstanden, wodurch sich auch Möglichkeiten zu ihrer Verhinderung eröffnen. Die therapeutische Hypothermie hat sich als wirksame Methode zur Neuroprotektion bei hypoxisch-ischämischer Enzephalopathie erwiesen. In diesem Kapitel werden diagnostische Möglichkeiten zur Beurteilung der neurologischen Funktion im Neugeborenenalter dargestellt. Klinische Erscheinungsformen und therapeutisches Vorgehen bei Fehlbildungen des zentralen Nervensystems, bei zerebralen Krampfanfällen, bei neonatalem Drogenentzug sowie bei intrakraniellen Blutungen werden beschrieben.

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Literatur

  1. Ahrens S, Ream MA, Slaughter LA (2019) Status epilepticus in the neonate: updates in treatment strategies. Curr Treat Options Neurol 21(2):8

    Article  PubMed  Google Scholar 

  2. Andersen JM, Høiseth G, Nygaard E (2020) Prenatal exposure to methadone or buprenorphine and long-term outcomes: a meta-analysis. Early Hum Dev 143:104997

    Article  CAS  PubMed  Google Scholar 

  3. Azzopardi D (2015) Clinical applications of cerebral function monitoring in neonates. Semin Fetal Neonatal Med 20(3):154–163

    Article  PubMed  Google Scholar 

  4. Badhiwala JH, Hong CJ, Nassiri F, Hong BY, Riva-Cambrin J, Kulkarni AV (2015) Treatment of posthemorrhagic ventricular dilation in preterm infants: a systematic review and meta-analysis of outcomes and complications. J Neurosurg Pediatr 16(5):545–555

    Article  PubMed  Google Scholar 

  5. Ballout RA, Foster JP, Kahale LA, Badr L (2017) Body positioning for spontaneously breathing preterm infants with apnoea. Cochrane Database Syst Rev 1(1):CD004951

    PubMed  Google Scholar 

  6. Bernardes da Cunha S, Carneiro MC, Miguel Sa M, Rodrigues A, Pina C (2021) Neurodevelopmental outcomes following prenatal diagnosis of isolated corpus callosum agenesis: a systematic review. Fetal Diagn Ther 48(2):88–95

    Article  PubMed  Google Scholar 

  7. Bittigau P, Sifringer M, Ikonomidou C (2003) Antiepileptic drugs and apoptosis in the developing brain. Ann N Y Acad Sci 993:103–114; discussion 123–104

    Article  CAS  PubMed  Google Scholar 

  8. Blair PS, Sidebotham P, Berry PJ, Evans M, Fleming PJ (2006) Major epidemiological changes in sudden infant death syndrome: a 20-year population-based study in the UK. Lancet 367(9507):314–319

    Article  PubMed  Google Scholar 

  9. Bohnhorst B, Cech K, Peter C, Doerdelmann M (2010) Oral versus nasal route for placing feeding tubes: no effect on hypoxemia and bradycardia in infants with apnea of prematurity. Neonatology 98(2):143–149

    Article  PubMed  Google Scholar 

  10. Booth D, Evans DJ (2004) Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev 18(4):CD004218

    Google Scholar 

  11. Brinjikji W, Krings T, Murad MH, Rouchaud A, Meila D (2017) Endovascular treatment of vein of Galen malformations: a systematic review and meta-analysis. AJNR Am J Neuroradiol 38(12):2308–2314

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Brouwer MJ, de Vries LS, Groenendaal F, Koopman C, Pistorius LR, Mulder EJ, Benders MJ (2012) New reference values for the neonatal cerebral ventricles. Radiology 262(1):224–233

    Article  PubMed  Google Scholar 

  13. Bruckner M, Pichler G, Urlesberger B (2020) NIRS in the fetal to neonatal transition and immediate postnatal period. Semin Fetal Neonatal Med 25(2):101079

    Article  PubMed  Google Scholar 

  14. Bruschettini M, Romantsik O, Zappettini S, Banzi R, Ramenghi LA, Calevo MG (2016) Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants. Cochrane Database Syst Rev 3:CD011636

    PubMed  Google Scholar 

  15. Carta S, Kaelin Agten A, Belcaro C, Bhide A (2018) Outcome of fetuses with prenatal diagnosis of isolated severe bilateral ventriculomegaly: systematic review and meta-analysis. Ultrasound Obstet Gynecol 52(2):165–173

    Article  CAS  PubMed  Google Scholar 

  16. Chari A, Mallucci C, Whitelaw A, Aquilina K (2021) Intraventricular haemorrhage and posthaemorrhagic ventricular dilatation: moving beyond CSF diversion. Childs Nerv Syst 37(11):3375–3383

    Article  PubMed  PubMed Central  Google Scholar 

  17. Cipowicz C, Schmid M, Hummler H, Thome U (2018) Correction: IVH prevention for ELBW preterm babies in two different perinatal centers. Z Geburtshilfe Neonatol 222(6):e2

    PubMed  Google Scholar 

  18. Cramer SJE, Dekker J, Dankelman J, Pauws SC, Hooper SB, Te Pas AB (2018) Effect of tactile stimulation on termination and prevention of apnea of prematurity: a systematic review. Front Pediatr 6:45

    Article  PubMed  PubMed Central  Google Scholar 

  19. Crowther CA, Crosby DD, Henderson-Smart DJ (2010) Phenobarbital prior to preterm birth for preventing neonatal periventricular haemorrhage. Cochrane Database Syst Rev 2010(1):CD000164

    PubMed  PubMed Central  Google Scholar 

  20. Crowther CA, Crosby DD, Henderson-Smart DJ (2010) Vitamin K prior to preterm birth for preventing neonatal periventricular haemorrhage. Cochrane Database Syst Rev 2010(1):CD000229

    PubMed  PubMed Central  Google Scholar 

  21. d’Arcangues C, Schulz M, Bührer C, Thome U, Krause M, Thomale UW (2018) Extended Experience with Neuroendoscopic Lavage for Posthemorrhagic Hydrocephalus in Neonates. World Neurosurg 116:e217–e224

    Article  PubMed  Google Scholar 

  22. Darnall RA, Kattwinkel J, Nattie C, Robinson M (1997) Margin of safety for discharge after apnea in preterm infants. Pediatrics 100(5):795–801

    Article  CAS  PubMed  Google Scholar 

  23. Davidoff AM (2021) Neonatal Neuroblastoma. Clin Perinatol 48(1):101–115

    Article  PubMed  Google Scholar 

  24. Davis PG, Henderson-Smart DJ (2003) Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants. Cochrane Database Syst Rev 2(2):CD000143

    Google Scholar 

  25. Deeg KH, Staudt F, von Rohden L (1999) Classification of intracranial hemorrhage in premature infants. Ultraschall Med 20(4):165–170

    CAS  PubMed  Google Scholar 

  26. Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D (2009) Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev (1):CD004661

    Google Scholar 

  27. Dunbar M, Mineyko A, Hill M, Hodge J, Floer A, Kirton A (2020) Population based birth prevalence of disease-specific perinatal stroke. Pediatrics 146(5):e2020013201

    Article  PubMed  Google Scholar 

  28. Falsaperla R, Scalia B, Giaccone F, Suppiej A, Pulvirenti A, Mailo J, Ruggieri M (2022) aEEG vs cEEG’s sensitivity for seizure detection in the setting of neonatal intensive care units: a systematic review and meta-analysis. Acta Paediatr 111(5):916–926

    Article  PubMed  Google Scholar 

  29. Faust K, Härtel C, Preuß M, Rabe H, Roll C, Emeis M, et al. (2015) Short-term outcome of very-low-birthweight infants with arterial hypotension in the first 24 h of life. Arch Dis Child Fetal Neonatal Ed 100(5):F388–F392

    Google Scholar 

  30. Finnegan LP (1985) Neonatal abstinence. In: Nelson NM (Hrsg) Current therapy in neonatal-perinatal medicine. Mosby, St. Louis

    Google Scholar 

  31. Fountain DM, Chari A, Allen D, James G (2016) Comparison of the use of ventricular access devices and ventriculosubgaleal shunts in posthaemorrhagic hydrocephalus: systematic review and meta-analysis. Childs Nerv Syst 32(2):259–267

    Article  PubMed  Google Scholar 

  32. Frazier LM, Bobby LE, Gawronski KM (2022) Emerging therapies for the treatment of neonatal abstinence syndrome. J Matern Fetal Neonatal Med 35(5):987–995

    Article  CAS  PubMed  Google Scholar 

  33. Garvey AA, Pavel AM, Murray DM, Boylan GB, Dempsey EM (2022) Does early cerebral near-infrared spectroscopy monitoring predict outcome in neonates with hypoxic ischaemic encephalopathy? A systematic review of diagnostic test accuracy. Neonatology 119(1):1–9

    Article  PubMed  Google Scholar 

  34. Gibson BL, Coe K, Bradshaw W (2019) Pharmacologic management of neonatal abstinence syndrome using a protocol. Adv Neonatal Care 19(6):482–489

    Article  PubMed  Google Scholar 

  35. Goeral K, Schwarz H, Hammerl M, Brugger J, Wagner M, Klebermass-Schrehof K, et al. (2021) Longitudinal reference values for cerebral ventricular size in preterm infants born at 23–27 weeks of gestation. J Pediatr 238:110–117.e112

    Google Scholar 

  36. Goldberg N, Rodriguez-Prado Y, Tillery R, Chua C (2018) Sudden infant death syndrome: a review. Pediatr Ann 47(3):e118–e123

    Article  PubMed  Google Scholar 

  37. Gossling L, Alix JJP, Stavroulakis T, Hart AR (2020) Investigating and managing neonatal seizures in the UK: an explanatory sequential mixed methods approach. BMC Pediatr 20(1):36

    Article  PubMed  PubMed Central  Google Scholar 

  38. Grevsen AK, Hviid CVB, Hansen AK, Hvas AM (2020) The role of platelets in premature neonates with intraventricular hemorrhage: a systematic review and meta-analysis. Semin Thromb Hemost 46(3):366–378

    Article  PubMed  Google Scholar 

  39. Guillot M, Sebastianski M, Lemyre B (2021) Comparative performance of head ultrasound and MRI in detecting preterm brain injury and predicting outcomes: a systematic review. Acta Paediatr 110(5):1425–1432

    Article  PubMed  Google Scholar 

  40. Hellström-Westas L, Boylan G, Ågren J (2015) Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment. Acta Paediatr 104(2):123–129

    Article  PubMed  Google Scholar 

  41. Henderson-Smart D, Steer P (2004) Doxapram treatment for apnea in preterm infants. Cochrane Database Syst Rev (4):CD000074

    Google Scholar 

  42. Henderson-Smart DJ, De Paoli AG (2010) Methylxanthine treatment for apnoea in preterm infants. Cochrane Database Syst Rev (12):CD000140

    Google Scholar 

  43. Henderson-Smart DJ, Steer PA (2010) Caffeine versus theophylline for apnea in preterm infants. Cochrane Database Syst Rev (1):CD000273

    Google Scholar 

  44. Hooper RG, Ramaswamy VV, Wahid RM, Satodia P, Bhulani A (2021) Levetiracetam as the first-line treatment for neonatal seizures: a systematic review and meta-analysis. Dev Med Child Neurol 63(11):1283–1293

    Article  PubMed  Google Scholar 

  45. Houtrow AJ, MacPherson C, Jackson-Coty J, Rivera M, Flynn L, Burrows PK, et al. (2021) Prenatal repair and physical functioning among children with myelomeningocele: a secondary analysis of a randomized clinical trial. JAMA Pediatr 175(4):e205674

    Google Scholar 

  46. Houtrow AJ, Thom EA, Fletcher JM, Burrows PK, Adzick NS, Thomas NH, et al. (2020) Prenatal repair of myelomeningocele and school-age functional outcomes. Pediatrics 145(2):e20191544

    Google Scholar 

  47. Humberg A, Härtel C, Paul P, Hanke K, Bossung V, Hartz A, et al. (2017) Delivery mode and intraventricular hemorrhage risk in very-low-birth-weight infants: observational data of the German Neonatal Network. Eur J Obstet Gynecol Reprod Biol 212:144–149

    Google Scholar 

  48. Hummler HD, Poets CF, Vochem M, Hentschel R, Linderkamp O (2006) Mortalität und Morbidität sehr unreifer Frühgeborener in Baden-Württemberg in Abhängigkeit von der Klinikgröße. Ist der derzeitige Grad der Regionalisierung ausreichend? Z Geburtsh Neonatol 210:6–11

    Article  CAS  Google Scholar 

  49. Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG (2013) Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013(1):CD003311

    PubMed  PubMed Central  Google Scholar 

  50. Jasani B, Torgalkar R, Ye XY, Syed S, Shah PS (2021) Association of umbilical cord management strategies with outcomes of preterm infants: a systematic review and network meta-analysis. JAMA Pediatr 175(4):e210102

    Article  PubMed  PubMed Central  Google Scholar 

  51. Joyeux L, De Bie F, Danzer E, Russo FM, Javaux A, Peralta CFA, et al. (2020) Learning curves of open and endoscopic fetal spina bifida closure: systematic review and meta-analysis. Ultrasound Obstet Gynecol 55(6):730–739

    Google Scholar 

  52. Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, et al. (2020) A randomized trial of erythropoietin for neuroprotection in preterm infants. N Engl J Med 382(3):233–243

    Google Scholar 

  53. Kandall SR, Gaines J, Habel L, Davidson G, Jessop D (1993) Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring. J Pediatr 123(1):120–126

    Article  CAS  PubMed  Google Scholar 

  54. Kandula V, Mohammad LM, Thirunavu V, LoPresti M, Beestrum M, Lai GY, Lam SK (2022) The role of blood product removal in intraventricular hemorrhage of prematurity: a meta-analysis of the clinical evidence. Childs Nerv Syst 38(2):239–252

    Article  PubMed  Google Scholar 

  55. Kariholu U, Montaldo P, Markati T, Lally PJ, Pryce R, Teiserskas J, et al. (2020) Therapeutic hypothermia for mild neonatal encephalopathy: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 105(2):225–228

    Google Scholar 

  56. Kecskes Z, Healy G, Jensen A (2005) Fluid restriction for term infants with hypoxic-ischaemic encephalopathy following perinatal asphyxia. Cochrane Database Syst Rev 2005(3):CD004337

    PubMed  PubMed Central  Google Scholar 

  57. Klinger G, Beyene J, Shah P, Perlman M (2005) Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia? Arch Dis Child Fetal Neonatal Ed 90(1):F49–F52

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Kocherlakota P (2014) Neonatal abstinence syndrome. Pediatrics 134(2):e547–e561

    Article  PubMed  Google Scholar 

  59. Lai GY, Chu-Kwan W, Westcott AB, Kulkarni AV, Drake JM, Lam SK (2021) Timing of temporizing neurosurgical treatment in relation to shunting and neurodevelopmental outcomes in posthemorrhagic ventricular dilatation of prematurity: a meta-analysis. J Pediatr 234:54–64.e20

    Article  PubMed  Google Scholar 

  60. Lapa DA, Chmait RH, Gielchinsky Y, Yamamoto M, Persico N, Santorum M, et al. (2021) Percutaneous fetoscopic spina bifida repair: effect on ambulation and need for postnatal cerebrospinal fluid diversion and bladder catheterization. Ultrasound Obstet Gynecol 58(4):582–589

    Google Scholar 

  61. Larson JJ, Graham DL, Singer LT, Beckwith AM, Terplan M, Davis JM, et al. (2019) Cognitive and behavioral impact on children exposed to opioids during pregnancy. Pediatrics 144(2):e20190514

    Google Scholar 

  62. Lee JJ, Chen J, Eisler L, Li G, Davis JM, Sun LS (2019) Comparative effectiveness of opioid replacement agents for neonatal opioid withdrawal syndrome: a systematic review and meta-analysis. J Perinatol 39(11):1535–1545

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Leijser LM, Scott JN, Roychoudhury S, Zein H, Murthy P, Thomas SP, Mohammad K (2021) Post-hemorrhagic ventricular dilatation: inter-observer reliability of ventricular size measurements in extremely preterm infants. Pediatr Res 90(2):403–410

    Article  PubMed  Google Scholar 

  64. Licci M, Guzman R, Soleman J (2019) Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review. Neurosurg Focus 47(4):E11

    Article  PubMed  Google Scholar 

  65. Lutz IC, Allegaert K, de Hoon JN, Marynissen H (2020) Pharmacokinetics during therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy: a literature review. BMJ Paediatr Open 4(1):e000685

    Article  PubMed  PubMed Central  Google Scholar 

  66. MacMillan KDL, Rendon CP, Verma K, Riblet N, Washer DB, Volpe Holmes A (2018) Association of rooming-in with outcomes for neonatal abstinence syndrome: a systematic review and meta-analysis. JAMA Pediatr 172(4):345–351

    Article  PubMed  PubMed Central  Google Scholar 

  67. Makarious L, Teng A, Oei JL (2022) SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants. Arch Dis Child Fetal Neonatal Ed 107(6):617–623

    Article  PubMed  Google Scholar 

  68. Marchand G, Masoud AT, Govindan M, Ware K, King A, Ruther S, et al. (2022) Birth outcomes of neonates exposed to marijuana in utero: a systematic review and meta-analysis. JAMA Netw Open 5(1):e2145653

    Google Scholar 

  69. McGoldrick E, Stewart F, Parker R, Dalziel SR (2020) Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev 12(12):CD004454

    PubMed  Google Scholar 

  70. Natalucci G, Latal B, Koller B, Rüegger C, Sick B, Held L, et al. (2016) Effect of early prophylactic high-dose recombinant human erythropoietin in very preterm infants on neurodevelopmental outcome at 2 years: a randomized clinical trial. JAMA 315(19):2079–2085

    Google Scholar 

  71. Natalucci G, Latal B, Koller B, Rüegger C, Sick B, Held L, Fauchère JC (2020) Neurodevelopmental outcomes at age 5 years after prophylactic early high-dose recombinant human erythropoietin for neuroprotection in very preterm infants. JAMA 324(22):2324–2327

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Nelson LF, Yocum VK, Patel KD, Qeadan F, Hsi A, Weitzen S (2020) Cognitive outcomes of young children after prenatal exposure to medications for opioid use disorder: a systematic review and meta-analysis. JAMA Netw Open 3(3):e201195

    Article  PubMed  PubMed Central  Google Scholar 

  73. Obladen M (2007) Mindestmengen in der Versorgung sehr untergewichtiger Frühgeborener: Eine Literaturubersicht. Z Geburtshilfe Neonatol 211(3):110–117

    Article  CAS  PubMed  Google Scholar 

  74. Obladen M, Metze B, Henrich W, Aktas A, Czernik C, Schulz-Baldes A (2008) Interdisciplinary surveillance of intraventricular haemorrhage associated conditions in infants <1000 g. Acta Paediatr 97(6):731–737

    Article  PubMed  Google Scholar 

  75. Pahl A, Young L, Buus-Frank ME, Marcellus L, Soll R (2020) Non-pharmacological care for opioid withdrawal in newborns. Cochrane Database Syst Rev 12(12):CD013217

    PubMed  Google Scholar 

  76. Papile LA, Burstein J, Burstein R, Koffler H (1978) Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 92(4):529–534

    Article  CAS  PubMed  Google Scholar 

  77. Pin TW, Eldridge B, Galea MP (2009) A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy. Eur J Paediatr Neurol 13(3):224–234

    Article  PubMed  Google Scholar 

  78. Pisani F, Spagnoli C (2016) Neonatal seizures: a review of outcomes and outcome predictors. Neuropediatrics 47(1):12–19

    Article  PubMed  Google Scholar 

  79. Poets CF, Roberts RS, Schmidt B, Whyte RK, Asztalos EV, Bader D, et al. (2015) Association between intermittent hypoxemia or bradycardia and late death or disability in extremely preterm infants. JAMA 314(6):595–603

    Google Scholar 

  80. Poryo M, Boeckh JC, Gortner L, Zemlin M, Duppré P, Ebrahimi-Fakhari D, et al. (2018) Ante-, peri- and postnatal factors associated with intraventricular hemorrhage in very premature infants. Early Hum Dev 116:1–8

    Google Scholar 

  81. Raitio A, Rice MJ, Mullassery D, Losty PD (2021) Stage 4S neuroblastoma: what are the outcomes? A systematic review of published studies. Eur J Pediatr Surg 31(5):385–389

    Google Scholar 

  82. Rees P, Stilwell PA, Bolton C, Akillioglu M, Carter B, Gale C, Sutcliffe A (2020) Childhood health and educational outcomes after neonatal abstinence syndrome: a systematic review and meta-analysis. J Pediatr 226:149–156.e116

    Article  PubMed  Google Scholar 

  83. Romantsik O, Calevo MG, Bruschettini M (2020) Head midline position for preventing the occurrence or extension of germinal matrix-intraventricular haemorrhage in preterm infants. Cochrane Database Syst Rev 7(7):CD012362

    PubMed  Google Scholar 

  84. Sabsabi B, Harrison A, Banfield L, Mukerji A (2021) Nasal intermittent positive pressure ventilation versus continuous positive airway pressure and apnea of prematurity: a systematic review and meta-analysis. Am J Perinatol 39(12):1314-1320

    Google Scholar 

  85. Salhab WA, Wyckoff MH, Laptook AR, Perlman JM (2004) Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia. Pediatrics 114(2):361–366

    Article  PubMed  Google Scholar 

  86. Sanz Cortes M, Chmait RH, Lapa DA, Belfort MA, Carreras E, Miller JL, et al. (2021) Experience of 300 cases of prenatal fetoscopic open spina bifida repair: Report of the International Fetoscopic Neural Tube Defect Repair Consortium. Am J Obstet Gynecol 225(6):678.e671–678.e611

    Google Scholar 

  87. Sarnat HB, Sarnat MS (1976) Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 33(10):696–705

    Article  CAS  PubMed  Google Scholar 

  88. Schmidt B, Anderson PJ, Doyle LW, Dewey D, Grunau RE, Asztalos EV, et al. (2012) Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity. JAMA 307(3):275–282

    Google Scholar 

  89. Schmidt B, Roberts RS, Anderson PJ, Asztalos EV, Costantini L, Davis PG, et al. (2017) Academic performance, motor function, and behavior 11 years after neonatal caffeine citrate therapy for apnea of prematurity: an 11-year follow-up of the CAP randomized clinical trial. JAMA Pediatr 171(6):564–572

    Google Scholar 

  90. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, et al. (2006) Caffeine therapy for apnea of prematurity. N Engl J Med 354(20):2112–2121

    Google Scholar 

  91. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, et al. (2007) Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med 357(19):1893–1902

    Google Scholar 

  92. Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, et al. (2020) Levetiracetam versus phenobarbital for neonatal seizures: a randomized controlled trial. Pediatrics 145(6):e20193182

    Google Scholar 

  93. Smit E, Odd D, Whitelaw A (2013) Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants. Cochrane Database Syst Rev 2013(8):CD001691

    Google Scholar 

  94. Sorg AL, Von Kries R, Klemme M, Gerstl L, Beyerlein A, Lack N, et al. (2021) Incidence and risk factors of cerebral sinovenous thrombosis in infants. Dev Med Child Neurol 63(6):697–704

    Google Scholar 

  95. Sorg AL, von Kries R, Klemme M, Gerstl L, Weinberger R, Beyerlein A, et al. (2020) Risk factors for perinatal arterial ischaemic stroke: a large case-control study. Dev Med Child Neurol 62(4):513–520

    Google Scholar 

  96. Synnes AR, Macnab YC, Qiu Z, Ohlsson A, Gustafson P, Dean CB, Lee SK (2006) Neonatal intensive care unit characteristics affect the incidence of severe intraventricular hemorrhage. Med Care 44(8):754–759

    Article  PubMed  Google Scholar 

  97. Thompson CM, Puterman AS, Linley LL, Hann FM, van der Elst CW, Molteno CD, Malan AF (1997) The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr 86(7):757–761

    Article  CAS  PubMed  Google Scholar 

  98. Toet MC, Hellström-Westas L, Groenendaal F, Eken P, de Vries LS (1999) Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 81(1):F19–F23

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Twist CJ, Naranjo A, Schmidt ML, Tenney SC, Cohn SL, Meany HJ, et al. (2019) Defining risk factors for chemotherapeutic intervention in infants with stage 4s neuroblastoma: a report from Children’s Oncology Group Study ANBL0531. J Clin Oncol 37(2):115–124

    Google Scholar 

  100. van Handel M, Swaab H, de Vries LS, Jongmans MJ (2007) Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. Eur J Pediatr 166(7):645–654

    Article  PubMed  PubMed Central  Google Scholar 

  101. van Wincoop M, de Bijl-Marcus K, Lilien M, van den Hoogen A, Groenendaal F (2021) Effect of therapeutic hypothermia on renal and myocardial function in asphyxiated (near) term neonates: a systematic review and meta-analysis. PLoS One 16(2):e0247403

    Article  PubMed  PubMed Central  Google Scholar 

  102. Vliegenthart RJ, Ten Hove CH, Onland W, van Kaam AH (2017) Doxapram treatment for apnea of prematurity: a systematic review. Neonatology 111(2):162–171

    Article  PubMed  Google Scholar 

  103. Whitelaw A, Kennedy CR, Brion LP (2001) Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation. Cochrane Database Syst Rev 2001(2):CD002270

    PubMed  PubMed Central  Google Scholar 

  104. Whitelaw A, Lee-Kelland R (2017) Repeated lumbar or ventricular punctures in newborns with intraventricular haemorrhage. Cochrane Database Syst Rev 4(4):CD000216

    PubMed  Google Scholar 

  105. Whitelaw A, Odd DE (2007) Intraventricular streptokinase after intraventricular hemorrhage in newborn infants. Cochrane Database Syst Rev 2007(4):CD000498

    PubMed  PubMed Central  Google Scholar 

  106. Wiese-Posselt M, Tertilt C, Zepp F (2011) Vaccination recommendations for Germany. Dtsch Arztebl Int 108(45):771–779; quiz 780

    PubMed  PubMed Central  Google Scholar 

  107. Wilson RD, O’Connor DL (2022) Guideline No. 427: folic acid and multivitamin supplementation for prevention of folic acid-sensitive congenital anomalies. J Obstet Gynaecol Can 44(6):707–719.e701

    Article  PubMed  Google Scholar 

  108. Wolf HT, Weber T, Schmidt S, Norman M, Varendi H, Piedvache A, et al. (2021) Mode of delivery and adverse short- and long-term outcomes in vertex-presenting very preterm born infants: a European population-based prospective cohort study. J Perinat Med 49(7):923–931

    Google Scholar 

  109. Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, et al. (2022) Trial of erythropoietin for hypoxic-ischemic encephalopathy in newborns. N Engl J Med 387(2):148–159

    Google Scholar 

  110. Yeo KT, Thomas R, Chow SS, Bolisetty S, Haslam R, Tarnow-Mordi W, Lui K (2020) Improving incidence trends of severe intraventricular haemorrhages in preterm infants <32 weeks gestation: a cohort study. Arch Dis Child Fetal Neonatal Ed 105(2):145–150

    Article  PubMed  Google Scholar 

  111. Yeoh SL, Eastwood J, Wright IM, Morton R, Melhuish E, Ward M, Oei JL (2019) Cognitive and motor outcomes of children with prenatal opioid exposure: a systematic review and meta-analysis. JAMA Netw Open 2(7):e197025

    Article  PubMed  PubMed Central  Google Scholar 

  112. Young L, Berg M, Soll R (2016) Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia. Cochrane Database Syst Rev 2016(5):CD001240

    PubMed  PubMed Central  Google Scholar 

  113. Zankl A, Martin J, Davey JG, Osborn DA (2021) Opioid treatment for opioid withdrawal in newborn infants. Cochrane Database Syst Rev 7(7):CD002059

    PubMed  Google Scholar 

  114. Zankl A, Martin J, Davey JG, Osborn DA (2021) Sedatives for opioid withdrawal in newborn infants. Cochrane Database Syst Rev 5(5):CD002053

    PubMed  Google Scholar 

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  1. Zentrum für Kinder- und Jugendmedizin, Philipps-Universität Marburg, Marburg, Deutschland

    Rolf F. Maier

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© 2023 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature

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Maier, R.F. (2023). Erkrankungen des Nervensystems. In: Obladens Neugeborenenintensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-66572-5_10

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  • DOI: https://doi.org/10.1007/978-3-662-66572-5_10

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