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Stimmungsstabilisatoren

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Neuro-/Psychopharmaka im Kindes- und Jugendalter

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Zusammenfassung

Stimmungsstabilisatoren sind Mittel der Wahl bei der Behandlung von bipolaren Störungen, einer Unterkategorie von affektiven Störungen. Diese beseitigen oder dämpfen die starken Stimmungsschwankungen, die mit den Krankheitsepisoden verbunden sind, sowie die Affektlabilität während und zwischen den Episoden. Ein idealer Stimmungsstabilisator wirkt sowohl in manischen, gemischten als auch depressiven Phasen und verhindert deren Wiederauftreten. Stimmungsstabilisatoren sind eine heterogene chemische und pharmakologische Wirkstoffklasse. Dazu gehören Lithiumsalze und Valproinsäure als klassische Vertreter sowie Antiepileptika mit stimmungsstabilisierenden Wirkungen (wie Carbamazepin, Gabapentin, Lamotrigin, Oxcarbazepin und Topiramat) und Antipsychotika der zweiten Generation (wie Aripiprazol, Olanzapin, Risperidon, Quetiapin und Ziprasidon). In diesem Kapitel wird zunächst ein kurzer Überblick zu den Erklärungsmodellen der Wirkmechanismen von Stimmungsstabilisatoren gegeben. Es werden dann wichtige Aspekte der klinischen Psychopharmakologie wie Indikationen, klinische Wirksamkeit und Studienlage, Dosierungen, Arzneimittelwechselwirkungen, Anwendungseinschränkungen, Dauer der Behandlung und Kontrolluntersuchungen als Orientierungshilfe für die klinische Anwendung besprochen.

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Authors and Affiliations

  1. Klinik und Poliklinik für Kinder- u. Jugendpsychiatrie, Psychosomatik u. Psychotherapie, Universitätsklinikum Würzburg, Zentrum für Psychische Gesundheit, Füchsleinstraße 15, 97080, Würzburg, Deutschland

    Dr. med. Laura Albantakis

  2. Klinik und Poliklinik für Kinder- u. Jugendpsychiatrie, Psychosomatik u. Psychotherapie, Universitätsklinikum Würzburg, Zentrum für Psychische Gesundheit, Füchsleinstraße 15, 97080, Würzburg, Deutschland

    Prof. Dr. rer. nat. Manfred Gerlach & Prof. Dr. med. Andreas Warnke

Authors
  1. Dr. med. Laura Albantakis
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  2. Prof. Dr. rer. nat. Manfred Gerlach
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  3. Prof. Dr. med. Andreas Warnke
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Correspondence to Manfred Gerlach .

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Editors and Affiliations

  1. Zentrum für Seelische Gesundheit, Universitätsklinikum Würzburg, Würzburg, Germany

    Manfred Gerlach

  2. Privatklinik für Seelische Gesundheit, J, HEMERA Klinik, Bad Kissingen, Germany

    Claudia Mehler-Wex

  3. Zentrum für Kinder- und Jugendpsychiatri, Universität Zürich, Zürich, Zürich, Switzerland

    Susanne Walitza

  4. Zentrum für Seelische Gesundheit, Universitätsklinikum Würzburg, Würzburg, Bayern, Germany

    Andreas Warnke

  5. Abteilung Kinder Jugendpsychiatrie, Kliniken der Stadt Köln gGmbH, Köln, Germany

    Christoph Wewetzer

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Albantakis, L., Gerlach, M., Warnke, A. (2016). Stimmungsstabilisatoren. In: Gerlach, M., Mehler-Wex, C., Walitza, S., Warnke, A., Wewetzer, C. (eds) Neuro-/Psychopharmaka im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48624-5_9

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