Zusammenfassung
Unter der Wirkstoffklasse Anxiolytika und Sedativa/Hypnotika wird eine sehr heterogene Gruppe von Neuro-/Psychopharmaka zusammengefasst. Trotz unterschiedlicher Wirkmechanismen haben sie ein gemeinsames klinisches Wirkungsspektrum und werden zur symptomatischen Behandlung von Angsterkrankungen und Schlafstörungen eingesetzt. Diese Stoffklasse ist aufgrund des dosisabhängigen kontinuierlichen Wirkungsspektrums von Anxiolyse über Sedierung und Schlaf bis Narkose nicht klar voneinander abgrenzbar. In diesem Kapitel wird der Wissensstand der in der Kinder- und Jugendpsychiatrie verwendeten Anxiolytika und Sedativa/Hypnotika hinsichtlich Wirkmechanismen, zugelassenen Indikationen, Studienlage zur Wirksamkeit und Sicherheit, Dosierungen, unerwünschten Arzneimittelwirkungen, Pharmakawechselwirkungen, Kontraindikationen und besonderen Vorsichtsmaßnahmen zusammengefasst. Mithilfe dieses Wissens sollen klinisch tätige Ärzte diese Neuro-/Psychopharmaka individuell, wirksam und sicher anwenden können.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
Literatur
Weiterführende Literatur
Bandelow B, Lichte T, Rudolf S, Wiltink J, Beutel ME (2014) Clinical practice guideline: The diagnosis of and treatment recommendations for anxiety disorders. Dtsch Arztbl Int 111:473–480
Möhler H (2011) The rise of a new GABA pharmacology. Neuropharmacology 60:1042–1049
Schatzberg AF, Nemeroff CB (Hrsg) (2009) Textbook of psychopharmacology, 4. Aufl. American Psychiatric Publishing, Washington
Stieler-Melfsen S, Walitza S (Hrsg) (2013) Soziale Angst und Schulangst. Entwicklungsrisiken erkennen und behandeln. Beltz, Weinheim
Zitierte Literatur
AACAP Official Action (2007) Practice parameter for the assessment and treatment of children and adolescents with anxiety disorders. J Am Acad Child Psy 46:267–283
Baldwin DS, Anderson IM, Nutt DJ et al (2014) Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol 28:403–439
Bandelow B, Zohar J, Hollander E, Kasper S, Möller H-J (2008) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders – First revision. World J Biol Psychia 9:248–312 (WFSBP Task Force on Treatment Guidelines for Anxiety Obsessive-Compulsive Post-Traumatic Stress Disorders)
Bezchlibnyk-Butler KZ, Virani AS (Hrsg) (2007) Clinical handbook of psychotropic drugs for children and adolescents, 2. Aufl. Hogrefe & Huber, Cambridge
Beidel DC, Turner SM, Sallee FR, Ammerman RT, Crosby LA, Pathak S (2007) SET-C versus fluoxetine in the treatment of childhood social phobia. J Am Acad Child Psy 46:1622–1632
Berney T, Kolvin I, Bhate SR, Garside RF, Jeans J, Kay B, Scarth L (1981) School phobia: a therapeutic trial with clomipramine and short-term outcome. Brit J Psychiat 138:110–118
Bernstein GA, Garfinkel BD, Borchardt CM (1990) Comparative studies of pharmacotherapy for school refusal. J Am Acad Child Psy 29:773–781
Bernstein GA, Borchardt CM, Perwien AR, Crosby RD, Kushner MG, Thuras PD, Last CG (2000) Imipramine plus cognitive-behavioral therapy in the treatment of school refusal. J Am Acad Child Psy 39:276–283
Birmaher B, Axelson DA, Monk K et al (2003) Fluoxetine for the treatment of childhood anxiety disorders. J Am Acad Child Psy 42:415–423
Buscemi N, Vandermeer B, Friesen C et al (2007) The efficacy and safety of drug treatment for chronic insomnia in adults: a mety-analyis of RCTs. J Gen Intern Med 22:1335–1350
Da Costa CZG, de Morais RMCB, Zanetta DMT et al (2013) Comparison among clomiparamine, fluoxetine, and placebo for the treatment of anxiety disorders in children and adolescents. J Child Adol Psychopharmacol 23:687–692
Dilling H, Mombour W, Schmidt MH (Hrsg) (2013) Internationale Klassifikation psychischer Störungen. ICD-10 Kapitel V (F) Klinisch-diagnostische Leitlinien, 9. Aufl. Huber, Bern
Domschke K (2013) Angsterkrankungen: Genetische Grundlagen. Neuroforum 3:118–125
Egberts K, Mehler-Wex C, Gerlach M (2011) Therapeutic drug monitoring in child and adolescent psychiatry. Pharmacopsychiatry 44:249–253
Falkai P, Wittchen H-U (Hrsg) (2015) American Psychiatric Association. Diagnostisches und Statistisches Manual Psychischer Störungen DSM-5. Hogrefe, Göttingen
Feinstein JS, Buzza C, Hurlemann R et al (2013) Fear und panic in humans with bilateral amygdala damage. Nat Neurosci 16:270–272
Gao K, Muzina D, Gajwani P, Calabrese JR (2006) Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review. J Clin Psychiat 67:1327–1340
Granville-Grossman KL, Turner P (1966) The effect of propranolol on anxiety. Lancet 1:788–790
Hiemke C, Baumann P, Bergemann N et al (2011) AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry – Update 2011. Pharmacopsychiatry 44:195–235 (The TDM group of the AGNP)
Hidalgo RB, Tupler LA, Davidson JR (2007) An effect-size analysis of pharmacologic treatments for generalized anxiety disorder. J Psychopharmacol 21:864–872
Ipser JC, Stein DJ, Hawkrige S, Hoppe L (2009) Pharmacotherapy for anxiety disorders in children and adolescents. Cochrane Database System Rev CD005170
Kasper S, Gastpar M, Müller WE, Volz H-P, Möller H-J, Schläfke S, Dienel A (2014) Lavender oil preparation Silexan is effective in generalized anxiety disorder – a randomized, double-blin comparison to placebo and paroxetine. Int J Neuropsychopharmacol 17:859–869
Klein RG, Koplewicz HS, Kanner A (1992) Imipramine treatment of children with separation anxitey disorder. J Am Acad Child Psy 31:21–28
March JS, Entusah AR, Rynn M, Albano AM, Tourian KA (2007) A randomized controlled trial of venlafaxine ER versus pedriatric social anxiety disorder. Biol Psychiat 62:1149–1154
Möhler H (2012) The GABA system in anxiety and depression and its therapeutic potential. Neuropharmacology 67:42–53
Möller HJ, Volz HP, Reimann IR, Stoll KD (2001) Opipramol for the treatment of generalized anxiety. A placebo controlled trial including an alprazolam treated group. J Clin Psychopharmacol 21:59–65
Morin CM, Koettler U, Bastien C, Ware JC, Wooten V (2005) Valerian-hops combination and diphenhydramine for treating insomnia: A randomized placebo-controlled clinical trial. Sleep 28:1465–1471
Müller WE, Hartmann H (1995) Definition, Einteilung, Chemie. In: Riederer P, Laux G, Pöldinger W (Hrsg) Tranquilizer und Hypnotika. Neuro-Psychopharmaka. Ein Therapie-Handbuch, Bd. 2. Springer, Wien, S 1–12
Neubauer (2007) The evolution and development of insomnia pharmacotherapies. J Clin Sleep Med 3(Suppl):S11–S15
Pape H-C (2013) Furcht, Angst, Angsterkrankungen. Neuroforum 3:90–91
Rynn MA, Riddle MA, Young PP, Kunz MR (2007) Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trials. Am J Psychiat 164:290–300
Sachser N, Lesch K-P (2013) Das Zusammenspiel von Genotyp und Umwelt bei der Entwicklung von Furcht und Angst. Neuroforum 3:104–110
Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A (2011) Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. Eur Neuropsychopharm 21:841–860
Schuckit MA, Hesselbrock V (1994) Alcohol dependence and anxiety disorders: what is the relationship? Am J Psychiat 151:1723–1734
Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M (2008) Clinical guideline for the evaluation of chronic insomnia in adults. J Clin Sleep Med 4:487–504
Stieler-Melfsen S, Walitza S (Hrsg) (2013) Soziale Angst und Schulangst. Entwicklungsrisiken erkennen und behandeln. Weinheim, Basel
Strawn JR, Sakolsky DJ, Rynn MA (2012a) Psychopharmacologic treatment of children and adolescents with anxiety disorders. Child Adol Psych Cl 21:527–539
Strawn JF, Wehry AM, DelBello MP, Rynn MA, Strakowski S (2012b) Establishing the neurobiologic basic of treatment in children and adolescents with generalized anxiety disorder. Depress Anxiety 29:328–339
The Research Unit on Pediatric Psychopharmacology Anxiety Study Group (2001) Fluvoxamine for the treatment of anxiety disorders in children and adolecents. New Engl J Med 344:1279–1285
Wagner KD, Berard R, Stein MB et al (2004) A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder. Arch Gen Psychiat 61:1153–1162
Walkup JT, Albano AM, Piacentini J et al (2008) Cognitive behavioral therapy. Sertraline, or a combination in childhood anxiety. New Engl J Med 359:2753–2766
Wotjak CT, Pape H-C (2013) Neuronale Schaltkreise von Furchtgedächtnis und Furchtextinktion. Neuroforum 3:92–102
Zito JM, Safer DJ, dosReis S, Gardner JF, Boles M, Lynch F (2000) Trends in prescribing of psychotropic medications to preschoolers. JAMA 283:1025–1030
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Dang, SY., Gerlach, M., Renner, T., Warnke, A. (2016). Anxiolytika und Sedativa/Hypnotika. In: Gerlach, M., Mehler-Wex, C., Walitza, S., Warnke, A., Wewetzer, C. (eds) Neuro-/Psychopharmaka im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48624-5_7
Download citation
DOI: https://doi.org/10.1007/978-3-662-48624-5_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-48623-8
Online ISBN: 978-3-662-48624-5
eBook Packages: Medicine (German Language)