Definition
Extracellular matrix (ECM) remodeling is a series of quantitative and qualitative changes in ECM during neoplastic transformation facilitating tumor growth and metastasis.
Characteristics
ECM is produced and assembled by the cells it is surrounding. The main components of ECM include glycosaminoglycans (with predominant hyaluronic acid) and proteoaminoglycans (e.g., perlecan, aggrecan), noncollagenous glycoproteins (such as fibronectin, laminins, tenascin), collagens, and many other biologically important molecules involved in cell–cell and cell–matrix interactions as well as in matrix remodeling. ECM provides not only the mechanical support for the attachment and organization of cellular structures but is also actively involved in the exchange of information with cells and therefore in the regulation of many important processes such as cell proliferation, migration, differentiation, and survival. Cell–cell and cell–matrix interactions are mediated via adhesive proteins...
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References
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Matusiewicz, M. (2015). Extracellular Matrix Remodeling. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_2068
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DOI: https://doi.org/10.1007/978-3-662-46875-3_2068
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Publisher Name: Springer, Berlin, Heidelberg
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