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Allergene der Hausstaubmilbe und Diagnostik der Hausstaubmilbenallergie

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Molekulare Allergiediagnostik

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Zusammenfassung

In weiten Teilen der Erde ist Hausstaub der wichtigste Auslöser von allergischen Reaktionen, und mehr als 50 % aller Allergiker sind auf Hausstaubmilben sensibilisiert. Die spezifische Immuntherapie der Hausstaubmilbenallergie wird routinemäßig mit Allergenextrakten durchgeführt. Aufgrund der schlechten Qualität der Hausstaubmilbenextrakte ist diese ist jedoch weniger wirksam als Therapien mit Pollenextrakten. Daher wäre es vorteilhaft, die Diagnose und Immuntherapie der Hausstaubmilbenallergie mit gereinigten natürlichen oder rekombinant hergestellten Hausstaubmilbenallergenen durchzuführen. Obwohl bereits mehr als 20 Allergene der Hausstaubmilbe bekannt sind und die meisten davon als rekombinante Proteine hergestellt wurden, sind bisher nur wenige Hausstaubmilbenallergene für die Routinediagnostik verfügbar. Dieses Kapitel beschreibt Aspekte der Diagnostik und Therapie mit rekombinanten Hausstaubmilbenallergenen.

Der Beitrag basiert auf einer Publikation der Autoren, die 2013 im Allergo Journal erschienen ist (Vrtala S, Jörg Kleine-Tebbe J: Hausstaubmilbenallergene und ihre Bedeutung. Allergo J 2013; 22: 546–549) und nun als Buchkapitel aktualisiert und erweitert wurde.

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Authors and Affiliations

  1. Allergie- und Asthma-Zentrum Westend, Praxis Hanf, Ackermann und Kleine-Tebbe, Berlin, Deutschland

    PD Dr. Jörg Kleine-Tebbe

  2. Forschungsgruppe Klinische und Molekulare Allergologie, Forschungszentrum Borstel, Parkallee 22a, 23845, Borstel, Deutschland

    Dr. med. Skadi Kull

  3. Institut für Pathophysiologie und Allergieforschung, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich

    Prof. Dr. rer. nat. Susanne Vrtala

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  1. Prof. Dr. rer. nat. Susanne Vrtala
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  2. Dr. med. Skadi Kull
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  1. Allergie- und Asthma-Zentrum Westend, Praxis Hanf, Ackermann und Kleine-Tebbe, Berlin, Germany

    Jörg Kleine-Tebbe

  2. Universitätsklinikum Gießen und Marburg, Klinik für Dermatologie und Allergologie, Freiburg im Breisgau, Germany

    Thilo Jakob

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Vrtala, S., Kull, S., Kleine-Tebbe, J. (2015). Allergene der Hausstaubmilbe und Diagnostik der Hausstaubmilbenallergie. In: Kleine-Tebbe, J., Jakob, T. (eds) Molekulare Allergiediagnostik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45221-9_19

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