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Streptomycin

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Biosynthesis

Part of the book series: Antibiotics ((ANTIBIOTICS))

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Abstract

Streptomycin was discovered by Schatz, Bugie and Waksman (1944) in the culture media of certain strains of Streptomyces griseus. Great interest was aroused when it was found that this compound exhibited antibiotic activity against certain bacteria and particularly the organism responsible for tuberculosis. Stimulated by this, an intensive research effort began, which, within several years, resulted in marked advances in our knowledge of the chemistry, isolation, purification, production, and therapeutic usefulness of this new drug. In contrast to the above investigative efforts, definitive studies of the metabolic pathways, by which this antibiotic is synthesized have been sparce until recent years. Indeed, over a decade has passed since its discovery, and detailed mechanisms of streptomycin formation still remain obscure.

The survey of literature for this chapter was concluded September, 1966.

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  1. W. H. Horner
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Editors and Affiliations

  1. Department of Plant Pathology, University of Illinois, Urbana, Illinois, USA

    David Gottlieb (Professor of Plant Pathology) (Professor of Plant Pathology)

  2. University of Illinois, Urbana, Illinois, USA

    Paul D. Shaw (Associate Professor of Biochemistry) (Associate Professor of Biochemistry)

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© 1967 Springer-Verlag Berlin Heidelberg

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Horner, W.H. (1967). Streptomycin. In: Gottlieb, D., Shaw, P.D. (eds) Biosynthesis. Antibiotics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38441-1_29

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  • DOI: https://doi.org/10.1007/978-3-662-38441-1_29

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