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Immune Aspects of Sunscreens

  • Chapter
Sunscreen Photobiology: Molecular, Cellular and Physiological Aspects

Part of the book series: Biotechnology Intelligence Unit ((BIOIU))

Abstract

Exposing the skin to ultraviolet (UV) radiation induces many biologic alterations, including a variety of effects on the immune system (reviewed in refs. 1,2). For example, UV radiation suppresses cell-mediated immune responses and can lead to a state of long-term, antigen-specific, immune suppression. In mice, UV-induced immune suppression contributes to the development of skin cancer. There is evidence that UV-induced alterations in immune function also play a significant role in skin carcinogenesis in humans. In addition, UV-induced immune suppression increases the severity of infectious diseases in animal models,1,3 and may contribute to the pathogenesis of some infectious diseases in humans. Sunscreens are designed primarily to prevent the acute effects of UV radiation.4 Their efficacy is indicated by a sun protection factor (SPF), which is based on their ability to prevent erythema in human skin. The quest for better sunscreens resulted in significant improvements, leading to preparations with SPFs of 40 or more. These preparations are highly protective against the acute effect of UV radiation, i.e., the sunburn reaction. In animal studies, sunscreens also protected against chronic UV-induced skin aging,5 tumor initiation,6,7 and tumor promotion.8

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Authors
  1. Peter Wolf
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  2. Margaret L. Kripke
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Editors and Affiliations

  1. Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, 233 South 10th St. (BLSB 428), Philadelphia, PA, 19107, USA

    Francis P. Gasparro Ph.D.

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Wolf, P., Kripke, M.L. (1997). Immune Aspects of Sunscreens. In: Gasparro, F.P. (eds) Sunscreen Photobiology: Molecular, Cellular and Physiological Aspects. Biotechnology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10135-3_7

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  • DOI: https://doi.org/10.1007/978-3-662-10135-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10137-7

  • Online ISBN: 978-3-662-10135-3

  • eBook Packages: Springer Book Archive

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