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Induction and Repression of NF-κB-Driven Inflammatory Genes

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Recent Advances in Glucocorticoid Receptor Action

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 40))

Abstract

Aberrant gene expression is a primary cause of many disease-associated pathophysiologies. Therefore, the pharmacological modulation of transcription factor activity represents an attractive therapeutic approach to such disorders. Except for nuclear receptors, which are a direct target of pharmaceuticals, other known classes of transcription factors are largely regulated indirectly, i.e., by drugs, which impact upon signal transduction cascades and alter transcription factor modification (phosphorylation, acetylation, nitrosylation, hydroxylation) and/or their nuclear import (Emery et al. 2001; Pandolfi 2001).

These authors contributed equally.

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  1. W. Vanden Berghe
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  2. K. De Bosscher
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  3. L. Vermeulen
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  4. G. De Wilde
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  5. G. Haegeman
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Editors and Affiliations

  1. Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, P.O. Box 3640, 76021, Karlsruhe, Germany

    A. C. B. Cato

  2. Research Business Area Dermatology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    H. Schäcke  & K. Asadullah  & 

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Vanden Berghe, W., De Bosscher, K., Vermeulen, L., De Wilde, G., Haegeman, G. (2002). Induction and Repression of NF-κB-Driven Inflammatory Genes. In: Cato, A.C.B., Schäcke, H., Asadullah, K. (eds) Recent Advances in Glucocorticoid Receptor Action. Ernst Schering Research Foundation Workshop, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04660-9_14

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  • DOI: https://doi.org/10.1007/978-3-662-04660-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

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