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Plasticity of Stem Cells

  • Conference paper
Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 33))

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Abstract

The interest in hematopoietic stem cells has increased over the past decades, because they are used as targets for gene transfer in gene therapy as well as serving as the source for bone marrow transplantation (BMT). BMT has become a well-established therapy, and its application has been extended to transplantation of unrelated individuals as well as older individuals. This is due to the use of less toxic or non-myeloablative conditioning protocols, the shortening of the duration of aplasia by the application of growth factors, and effective therapy of infectious disease or sepsis by potent antibiotic regimens. For many patients suffering from leukemia or myelodysplasic syndrome, BMT is the only therapeutic approach that potentially cures their disease. Currently, sources of hematopoietic stem cells for BMT are bone marrow (BM), mobilized peripheral blood stem cells (PBSC) and cord blood (CB). In particular, the use of PBSC has been increasing. When compared with BM, the collection of PBSC is of lower risk for the donor because there is no need for general anesthesia, the engraftment of stem cells is faster, and the number of collected immature CD34+ hematopoietic cells is higher. In the autologous setting, immature hematopoietic cells can be purified, e. g., by CD34-selection, to prevent contamination of the graft by tumor cells. However, do we know exactly which cells we have to collect? Do we know enough about human hematopoietic stem cells?

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Authors
  1. U. Kapp
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  2. R. Mertelsmann
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Editor information

W. Holzgreve M. Lessl

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© 2001 Springer-Verlag Berlin Heidelberg

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Kapp, U., Mertelsmann, R. (2001). Plasticity of Stem Cells. In: Holzgreve, W., Lessl, M. (eds) Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy. Ernst Schering Research Foundation Workshop, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04469-8_1

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  • DOI: https://doi.org/10.1007/978-3-662-04469-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-04471-1

  • Online ISBN: 978-3-662-04469-8

  • eBook Packages: Springer Book Archive

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