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Cellular Therapy pp 37–53Cite as

Recent Developments in the Ex Vivo Manipulation of Hematopoietic Cells from Bone Marrow and Blood

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Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 20))

Abstract

Transplantation of the hematopoietic system has become a more and more widely used tool within antitumor treatment regimens. In leukemias, the primary goal is to completely eradicate the malignant clone; however, autologous hematopoietic stem cell transplantation has also been introduced as treatment for a number of solid tumors in an effort to increase chemotherapy intensity beyond levels that are conventionally dose limiting due to life-threatening bone marrow toxicity. Recombinant hematopoietic growth factors have been of substantial benefit in improving engraftment kinetics (Lieschke 1992, for review). Especially the mobilization of progenitor cells from bone marrow into the peripheral blood has triggered a substantial extension of application fields for hematopoietic stem cell transfer, which now includes a variety of solid tumor disease states. This was mainly due to the much simplified logistics of harvesting peripheral blood progenitor cells (PBPC) without the need of general anesthesia. In most instances, the peripheral blood turned out to be a superior source of transplantable stem cells compared to progenitor cells from bone marrow, especially as the speed of neutrophil and platelet recovery was hastened (Brugger et al. 1993b, 1994b, 1995; Elias et al. 1992; Sheridan et al. 1992; To et al. 1992).

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Authors
  1. R. Henschler
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  2. J. Winkler
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  3. D. Möbest
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  4. A. Spyridonidis
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  5. W. Lange
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  6. R. Mertelsmann
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Editor information

H. Wekerle H. Graf J. D. Turner

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© 1997 Springer-Verlag Berlin Heidelberg

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Henschler, R., Winkler, J., Möbest, D., Spyridonidis, A., Lange, W., Mertelsmann, R. (1997). Recent Developments in the Ex Vivo Manipulation of Hematopoietic Cells from Bone Marrow and Blood. In: Wekerle, H., Graf, H., Turner, J.D. (eds) Cellular Therapy. Ernst Schering Research Foundation Workshop, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03509-2_3

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  • DOI: https://doi.org/10.1007/978-3-662-03509-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03511-5

  • Online ISBN: 978-3-662-03509-2

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