Abstract
The effects of thyroid hormones on postnatal growth, differentiation, and metabolism are well known. It is also recognized that thyroid hormones and glucocorticoids have complementary, and sometimes synergistic, effects on specific enzymes in several organs. Given this background information, it is not surprising that thyroid hormones were evaluated for effects on lung maturation and function shortly after recognition of glucocorticoid action. In this chapter I review the action of thyroid hormones in fetal and postnatal lung, describe properties of pulmonary T3 receptors and the correlations between binding and effect, and discuss preliminary information regarding clinical application.
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References
Abbassi V, Merchant K, Abramson D (1977) Postnatal triiodothyronine concentrations in healthy preterm infants and in infants with respiratory distress syndrome. Pediatr Res 11:802
Abbassi V, Adams J, Duvall D, Phillips E (1984) Prenatal thyroid function abnormalities in infants with idiopathic respiratory distress syndrome. Pediatr Res 18:926
Anderson CW, Conrad L, Cordero L (1982) Neonatal respiratory distress in the presence of amniotic fluid phosphatidylglycerol. Am J Obstet Gynecol 143:233
Ayromlooi J, Berg PD, Valderrama E, Tobias MD (1983) Midtrimester thyroidectomy in the ovine fetus. Pediatr Pharmacol 3:15
Azukizawa M, Murata Y, Ikenoue T, Martin CB Jr, Hershman JM (1976) Effect of thyrotropinreleasing hormone on secretion of thyrotropin, prolactin, thyroxine, and triiodothyronine in pregnant and fetal Rhesus monkeys. J Clin Endocrinol Metab 43:1020
Bachrach LK, Kudlow JE, Silverberg JDH, Kent G, Burrow GN (1982) Treatment of ovine cretinism in utero with 3,5-dimethyl-3’-isopropyl-L-thyronine. Endocrinology 111:132
Ballard PL, Benson BJ, Brehier A, Carter JP, Kriz BM, Jorgensen EC (1980) Transplacental stimulation of lung development in the fetal rabbit by 3,5-dimethyl-3’-isopropyl-L-thyronine. J Clin Invest 65:1407
Ballard PL, Kitterman JA, Bland RD, Clyman RI, Gluckman PD, Platzker ACG, Kaplan SL, Grumbach MM (1982) Ontogeny and regulation of corticosteroid binding globulin capacity in plasma of fetal and newborn lambs. Endocrinology 110:359
Ballard PL (1984) Combined hormonal treatment and lung maturation Seminars in Perinatology 8:283
Ballard PL, Hovey ML, Gonzales LK (1984) Thyroid hormone stimulation of phosphatidylcholine synthesis in cultured fetal rabbit lung. J Clin Invest 74:898
Baxter JD, Eberhardt NL, Apriletti JW, Johnson LK, Ivarie RD, Schachter BS, Morris JA, Seeburg PH, Goodman HM, Latham KR, Polansky JR, Martial JA (1979) Thyroid hormone receptors and responses. Rec Prog Horm Res 35:97
Bellabarba D, Bedard S, Fortier S, Lehous J-G (1983) 3,5,3’-triiodothyronine nuclear receptor in chick embryo. Properties and ontogeny of brain and lung receptors. Endocrinology 112:353
Bellabarba D, Fortier S, Belisle S, Lehous J-G (1984) Triiodothyronine nuclear receptors in liver, brain and lung of neonatal rats. Biol Neonate 45:41
Benson MC, Liu JP, Huang YP, Burger A, Rivlin RS (1978) Differential effects of triiodothyronine and 3,5-isopropyl-L-thyronine treatment of maternal rats upon hepatic L-triiodothyronine amino-transferase activity in fetal rats. Endocrinology 102:562
Bernal J, DeGroot LJ (1977) Thyroid hormone receptors: release of receptor to the medium during in vitro incubation of isolated rat liver nuclei. Endocrinology 100:648
Bernal J, Coleoni• AH, DeGroot LJ (1978) Thyroid hormone receptors from liver nuclei: characteristics of receptor from normal, thyroidectomized, and triiodothyronine-treated rats: measurement of occupied and unoccupied receptors, and chromatin binding of receptors. Endocrinology 103:403
Bernal J, Pekonen F (1984) Ontogenesis of the nuclear 3,5,3’-triiodothyronine receptor in the human fetal brain. Endocrinology 127:278
Bhakthavathsalan A, Mann LI, Tang LC, Erickson ND, Delamater PV, Damm C (1981) The effects of fetal thyroidectomy during the second trimester in the ovine fetus. Am J Obstet Gynecol 141:436
Burman KD, Read J, Dimond RC, Strum D, Wright FD, Patow W, Earll JM, Wartofsky L (1976) Measurements of 3,3’,5’-triiodothyronine (reverse T3), 3,3’-L-diiodothyronine, T3, and T4 in human amniotic fluid and in cord and maternal serum. J Clin Endocrinol Metab 43:1351
Chopra IJ (1977) A study of extrathryoidal conversion of thyroxine (T4) to 3,5,3’-triiodothyronine (T3) in vitro. Endocrinology 101:453
Chopra IJ (1978) Sulfhydryl group and the monodeiodination of thyroxine and triiodothyronine. Endocrinology 199:904
Chopra IJ (1981) Triiodothyronines in health and disease. Monographs on Endocrinology, Vol. 18, Springer, Berlin, Heidelberg, New York
Chopra IJ, Huang T-S, Hurd RE, Solomon DH (1984) A radioimmunoassay of 3,5-dimethy1–3’-isopropyl-L-thyronine. Endocrinology 114:1295
Chowdhry P, Scanlon JW, Auerbach R, Abbassi V (1984) Results of controlled double-blind study of thyroid replacement in very low-birth-weight premature infants with hypothyroxinemia. Pediatrics 73:301
Comite F, Burrow GN, Jorgensen EC (1978) Thryoid hormone analogs and fetal goiter. Endocrinology 102:1670
Coulombe P, Ruel J, Dussault JH (1979) Analysis of nuclear 3,5,3’-triiodothyronine-binding capacity and tissue response in the liver of the neonatal rat. Endocrinology 105:952
Cuestas RA, Linda11 A, Engel RR (1976) Low thyroid hormones and respiratory-distress syndrome of the newborn. Studies on cord blood. N Engl J Med 295:297
Cuestas RA, Engel RR (1979) Thyroid function in preterm infants with respiratory distress syndrome. J Pediatr 94:643
Das DK (1980) Fatty acid synthesis in fetal lung. Biochem Biophys Res Commun 92:867
Das DK, Ganguly M (1981) Diabetes, hypophysectomy, or thyroidectomy reduces nuclear L-triiodothyronine-binding capacity of rat lung. Endocrinology 109:296
Das DK (1983) Hormonal control of pulmonary surfactant synthesis. Arch Biochem Biophys 224:1
Das DK, Ayromlooi J, Bandyopadhyay D, Bandyopadhyay S, Neogi A, Steinberg H (1984) Potentiation of surfactant release in fetal lung by thyroid hormone action. J Appl Physiol: Respir Environ Exercise Physiol 56:1621
Dhanireddy R, Smith YF, Hamosh M, Mullon DK, Scanlon JW, Hamosh P (1983) Respiratory distress syndrome in the newborn: Relationship to serum prolactin, thyroxine, and sex. Biol Neonate 43:9
Dussault JH, Labrie F (1975) Development of the hypothalamic-pituitary-thyroid axis in the rat. Endocrinology 97:1321
Erenberg A, Omori K, Menkes JH, Oh W, Fisher DA (1974) Growth and development of the thyroidectomized ovine fetus. Pediatr Res 8:783
Erenberg A, Rhodes ML, Weinstein MM, Kennedy RL (1979) The effect of fetal thyroidectomy on ovine fetal lung maturation. Pediatr Res 13:230
Fisher DA, Lehman H, Lackey C (1964) Placental transport of thyroxine. J Clin Endocrinol Metab 24:393
Fisher DA, Dussault JH, Sack J, Chopra IJ (1977) Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep, and rat. Rec Prog Horm Res 33:59
Fisher DA, Klein AH (1981) Thyroid development and disorders of thyroid function in the newborn. N Engl J Med 304:702
Frieden E, Yoshizato K (1974) Thyromimetic activity of methyl thyronines in bullfrog tadpole. Endocrinology 95:188
Gonzales LW, Ballard PL (1981) Identification and characterization of nuclear 3,5,3’-triiodothyronine-binding sites in fetal human lung. J Clin Endocrinol Metab 53:21
Gonzales LW, Ballard PL (1982) Nuclear 3,5,3’-triiodothyronine receptors in rabbit lung: Characterization and developmental changes. Endocrinology 111:542
Gonzales LK, Ballard PL (1984) Glucocorticoid and thyroid hormone stimulation of phosphatidylcholine synthesis in cultured human fetal lung. Pediatr Res 18:310A (abstract)
Gorbman A, Evans HM (1943) Beginning of function in the thyroid of the fetal rat. Endocrinology 32:113
Granberg JP, Ballard PL (1977) The role of sulfhydryl groups in the binding of glucocorticoids by cytoplasmic receptors of lung and other mammalian tissues. Endocrinology 100:1160
Gross I, Wilson CM, Ingleson LD, Brehier A, Rooney SA (1980) Fetal lung in organ culture. III. Comparison of dexamethasone, thyroxine, and methylxanthines. J Appl Physiol: Respirat Environ Exercise Physiol 48:872
Gross I, Wilson CM (1982) Fetal lung in organ culture. IV. Super-additive hormone interaction. J Appl Physiol: Respirat Environ Exercise Physiol 52:1420
Gross I, Ballard PL, Ballard RA, Jones CT, Wilson CM (1983) Corticosteroid stimulation of phosphatidylcholine synthesis in cultured fetal rabbit lung: evidence for de novo protein synthesis mediated by glucocorticoid receptors. Endocrinology 112:829
Gross I, Dynia DW, Wilson CM, Ingleson LD, Gewolb IH, Rooney SA (1984) Glucocorticoidthyroid hormone interactions in fetal rat lung. Pediatr Res 18:191
Hadeed AJ, Asay LD, Klein AH, Fisher DA (1981) Significance of transient postnatal hypothyroxinemia in premature infants with and without respiratory distress syndrome. Pediatrics 68:494
Hamada S, Nakamura H, Nanno M, Imura H (1979) Triiodothyronine-induced increase in rat liver nuclear thyroid-hormone receptors associated with increased mitochondrial a-glycerophosphate dehydrogenase activity. Biochem J 182:371
Hitchcock KR, Reichlin S (1978) Thyroid hormones in the adult rat lung. Am Rev Resp Dis 117:807
Hitchcock KR (1979) Hormones and the lung. I. Thyroid hormones and glucocorticoids in lung development. Anat Rec 194:15
Hitchcock KR, Harney J, Reichlin S (1980) Hormones and the lung. III. Thyroid hormone uptake kinetics of perinatal rat lung. Endocrinology 107:294
Hopkins PS, Thorburn GD (1972) The effects of foetal thyroidectomy on the development of the ovine foetus. J Endocrinol 54:55
Ikegami M, Klein AH, Padbury JF, Jobe AH (1983) Does lung surfactant respond to thyroid hormones in fetal sheep? Pediatr Res 17:134A (abstract)
Jacobsen BB, Andersen H, Dige-Petersen H, Hummer L (1976) Thyrotropin response to thyroxine-releasing hormone in fullterm, euthyroid and hypothyroid newborns. Acta Paediatr Scand 65:433
Jacobsen BB, Andersen H, Dige-Petersen H, Hummer L (1977) Pituitary-thyroid responsiveness to thyrotropin-releasing hormone in preterm and small-for-gestational age newborns. Acta Paediatr Scand 66:541
Jorgensen EC, Murray WJ, Block P Jr (1974) Thyroxine analogs. XXII. Thyromimetic activity of halogen-free derivatives of 3,5-dimethyl-L-thyronine. J Med Chem 17:434
Jorgensen EC, Bolger MB, Dietrich SW (1976) Thyroid hormone analogs: correlations between structure, nuclear binding, and hormonal activity. Proceedings of the Fifth International Congress of Endocrinology, Vol 1, Excerpta Medica International Congress, p. 117
Jump DB, Oppenheimer JH (1983) Association of thyroid hormone receptors with chromatin. Molec Cell Biochem 55:159
Kauffman SL, Burri PH, Weibel ER (1974) The postnatal growth of the rat lung. II. Autoradiography. Anat Rec 180:63
Kitterman JA, Liggins GC, Campos GA, Clements JA, Forster CS, Lee CH, Creasy RK (1981) Prepartum maturation of the lung in fetal sheep: relation to cortisol. J Appl Physiol: Respirat Environ Exercise Physiol 51:384
Klein AH, Oddie TH, Fisher DA (1978) Effect of parturition on serum iodothyronine concentrations in fetal sheep. Endocrinology 103:1453
Klein AH, Foley B, Kenny FM, Fisher DA (1979) Thyroid hormone and thyrotropin responses to parturition in premature infants with and without the respiratory distress syndrome. Pediatrics 63:380
Klein AH, Murphy BEP, Artal R, Oddie TH, Fisher DA (1980) Amniotic fluid thyroid hormone concentrations during human gestation. Am J Obstet Gynecol 136:626
Klein AH, Fisher DA (1980) Thyrotropin-releasing hormone-stimulated pituitary and thyroid gland responsiveness and 3,5,3’-triiodothyronine suppression in fetal and neonatal lambs. Endocrinology 106:697
Klein AH, Foley B, Foley TP, MacDonald HM, Fisher DA (1981) Thyroid function studies in cord blood from premature infants with and without RDS. J Pediatr 98:818
Koerner D, Schwartz HL, Surks MI, Oppenheimer JH, Jorgensen EC (1975) Binding of selected iodothyronine analogs to receptor sites of isolated rat hepatic nuclei. J Biol Chem 250:6417
Korda AR, Fleming SF, Senior C, Duck-Chong CG, Henderson-Smart DJ, Ramsey G, Shutt DA, Russell P, Shearman RP (1984) The effect of intra-amniotic injection of triiodothyronine on pulmonary maturity in lambs at 130 days gestation. Pediatr Res 18:932
Kriz BM, Jones AL, Jorgensen EC (1978) Effects of a thyroid hormone analog on fetal rat hepatocyte ultrastructure and microsomal function. Endocrinology 102:712
Lindenberg JA, Brehier A, Ballard PL (1978) Triiodothyronine nuclear binding in fetal and adult rabbit lung and cultured lung cells. Endocrinology 103:1725
Longmuir KJ, Bleasdale JE, Quirk JG, Johnston JM (1982) Regulation of lamellar body acidic glycerophospholipid biosynthesis in fetal rabbit lung in organ culture. Biochem Biophys Acta 712:356
Lorijan RHW, Nelson JC, Longo LD (1980) Induced fetal hyperthyroidism: cardiac output and oxygen consumption. Am J Physiol 239:H302
Mariash CN, Oppenheimer JH (1983) Interrelationship of triiodothyronine concentration, metabolism, protein binding, and nuclear occupancy in the induction of malic enzyme by cultured adult rat hepatocytes. Endocrinology 112:80
Mashiach S, Barkai G, Sack J, Stern E, Goldman B, Brish M, Serr DM (1978) Enhancement of fetal lung maturity by intra-amniotic administration of thyroid hormone. Am J Obstet Gynecol 130:289
Mashiach S, Barkai G, Sack J, Stern E, Brish M, Goldman B, Serr DM (1979) The effect of intraamniotic thyroxine administration on fetal lung maturity in man. J Perinat Med 7:161
Mason RJ, Manganiello V, Vaughan M (1972) Effect of thyroxine on the disaturated lecithin content of lung. Am Rev Respir Dis 106:767
Melmed S, Harada A, Murata Y, Socol M, Reed A, Carlson HE, Azukizawa M, Martin C, Jorgensen E, Hershman JM (1979) Fetal response to thyrotropin-releasing hormone after thyroid hormone administration to the rhesus monkey: Lack of pituitary suppression. Endocrinology 105:334
Morishige WK, Guernsey DL (1978) Triiodothyronine receptors in rat lung. Endocrinology 102:1628
Morishige WK, Joun NS, Guernsey DL (1982) Thyroidal influence on postnatal lung development in the rat. Endocrinology 110:444
Neufeld N, Melmed S (1981) 3,5-dimethyl-3’-isopropyl-L-thyronine therapy in diabetic pregnancy. J Clin Invest 68:1605
Nwosu UC, Kaplan MM, Utiger RD, Delivoria-Papadopulos M (1978) Surge of fetal plasma triiodothyronine before birth in sheep. Am J Obstet Gynecol 132:489
Nwosu UC, Anday EK, Bolognese RJ, Bongiovanni AM, Delivoria-Papadopulos M (1980) Effect of in utero intravenous administration of thyroxine and other hormones on the lung fluid lecithin/spingomyelin ratio in the fetal lamb. Am J Obstet Gynecol 138:459
Oppenheimer JH, Samuels HH (eds) Molecular Basis of Thyroid Hormone Action, Academic Press, New York, 1983
Oppenheimer JH, Schwartz HL, Dillman W, Surks MI (1973) Effect of thyroid hormone analogs on the displacement of 125I-L-triiodothyronine from hepatic and heart nuclei in vivo: possible relationship to hormonal activity. Biochem Biophys Res Commun 55:544
Oppenheimer JH, Schwartz HL, Surks MI (1974) Tissue differences in the concentration of triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary, heart, brain, spleen and testis. Endocrinology 95:897
Papavasiliou SS, Martial JA, Latham KR, Baxter JD (1977) Thyroid hormone-like actions of 3,3’,5’-L-triiiodothyronine and 3,3’-diiodothyronine. J Clin Invest 60:1230
Raiti S, Holzman GB, Scott RL, Moser RM (1967) Evidence for the placental transfer of triiodothryonine in human beings. N Engl J Med 277:156
Redding RA, Douglas WHJ (1972) Thyroid hormone influence upon lung surfactant metabolism. Science 175:994
Redding RA, Pereira C (1974) Thyroid function in respiratory distress syndrome (RDS) of the newborn. Pediatrics 54:423
Rooney SA, Gross I, Gassenheimer LN, Motoyama EK (1975) Stimulation of glycerolphosphate phosphatidyltransferase activity in fetal rabbit lung by cortisol administration. Biochim Biophys Acta 398:433
Rooney SA, Marino PA, Gobran LI, Gross I, Warshaw JB (1979) Thyrotropin-releasing hormone increases the amount of surfactant in lung lavage from fetal rabbits. Pediatr Res 13:623
Roti E, Gnudi A, Braverman LE, Robuschi G, Emanuele R, Bandivi P, Benassi L, Pagliani A, Emerson CH (1981) Human cord blood concentrations of thyrotropin, thyroglobulin, and iodoothyronines after maternal administration of thyrotropin-releasing hormone. J Clin Endocrinol Metab 53:813
Ruel J, Coulombe P, Dussault JH (1982a) Thyroid hormones, malnutrition, and biochemical composition of developing rat lung. Am J Physiol (Endocrinol Metab):E378
Ruel J, Coulombe P, Dussault JH (1982b) Characterization of nuclear 3,5,3’-triiodothyronine receptors in the developing rat lung: Effects of hypo-and hyperthyroidism. Pediatr Res 16:238
Sack J, Mashiach S, Barkai G, Lunenfeld B, Brish M, Goldman B, Serr DM (1979) Intra-amniotic thyroxine absorption of the premature human fetus. Acta Endocrinol 90:361
Samuels HH, Tsai JS (1974) Thyroid hormone action. Demonstration of similar receptors in isolated nuclei of rat liver and cultured GH1 cells. J Clin Invest 53:656
Samuels HH, Stanley F, Shapiro LE (1976) Dose-dependent depletion of nuclear receptors by Ltriiodothyronine: evidence for a role in induction of growth hormone synthesis in cultured GHl cells. Proc Natl Acad Sci USA 11:3877
Samuels HH, Stanley F, Shapiro LE (1977) Modulation of thyroid hormone nuclear receptor levels by 3,5,3’-triiodo-L-thyronine in Gill cells: evidence for two functional components of nuclear-bound receptor and relationship to the induction of growth hormone synthesis. J Biol Chem 252:6052
Schreyer P, Caspi E, Letko Y, Ron-El R, Pinto N, Zeidman JL (1982) Intraamniotic triiodothyronine instillation for prevention of respiratory distress syndrome in pregnancies complicated by hypertension. J Perinat Med 10:27
Segall-Blank M, Douglas WHJ, Sanders RL, Hitchcock KR (1983) Thyroxine metabolism in cultured cells derived from fetal rat lung. Pediatr Res 17:596
Silva ES, Astier H, Thakare U, Schwartz H, Oppenheimer J (1977) Partial purification of the triiodothyronine receptor from rat liver nuclei. J Biol Chem 252:6799
Smith BT, Torday JS (1974) Factors affecting lecithin synthesis by fetal lung cells in culture. Pediatr Res 8:848
Smith BT, Sabry K (1983) Glucocorticoid-thyroid synergism in lung maturation: A mechanism involving epithelial-mesenchymal interaction. Proc Natl Acad Sci USA 80:1951
Smith DW, Klein AM, Henderson JR, Myrianthopoulos NC (1975) Congenital hypothyroidism signs and symptoms in the newborn period. J Pediatr 87:958
Spitzer HL, Johnston JM (1978) Characterization of phosphatidate phosphohydrolase activity associated with isolated lamellar bodies. Biochem Biophys Acta 531:275
Tamagna EI, Hershman JM, Jorgensen EC (1979) Thyrotropin suppression by 3,5-dimethyl-3’-isopropyl-L-thyronine in man. J Clin Endocrinol Metab 48:196
Thomas AL, Krane EJ, Nathanielsz PW (1978) Changes in the fetal thyroid axis after induction of premature parturition by low dose continuous intravascular cortisol infusion to the fetal sheep at 130 days of gestation. Endocrinology 103:17
Torday JS, Dow KE (1984) Synergistic effect of triiodothyronine and dexamethasone on male and female fetal rat lung surfactant synthesis. Dev Pharmacol Ther 7:133
Waterman AJ, Gorbman A (1956) Development of the thyroid gland of the rabbit. J Exp Zoolog 132:509
Wilson M, Hitchcock KR, Douglas WHJ, DeLellis RA (1979) Hormones and the lung II Immunohistochemical localization of thyroid hormone binding in type II pulmonary epithelial cells clonally-derived from adult rat lung. Anat Rec 195:611
Wrutniak C, Cabello G (1983) Changes in the concentration of thyroxine in the plasma of rat fetuses during late gestation: influence of ligation of the maternal uterine vein and artery. J Endocrinol 99:233
Wu B, Kikkawa Y, Orzalesi MM, Motoyama EK, Kaibara M, Zigas CJ, Cook CD (1973) The effect of thyroxine on the maturation of fetal rabbit lung. Biol Neonate 22:161
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Ballard, P.L. (1986). Thyroid Hormones: Effects and Binding. In: Hormones and Lung Maturation. Monographs on Endocrinology, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82483-8_7
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