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Somatostatin Receptor Scintigraphy in the Diagnosis of Neuroendocrine Gastroenteropancreatic Tumors

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New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 142))

Abstract

Somatostatin receptor scintigraphy is a new, very sensitive procedure for detecting receptor-positive neuroendocrine tumors. Radiolabeled somatostatin analogues are selectively taken up after intravenous administration by tissue carrying somatostatin receptors and, as with the skeletal scintiscan, permit a whole-body visualization of receptor-positive tumors and metastases. Somatostatin receptor scintigraphy shows an overall sensitivity of about 84% for neuroendocrine gastroenteropancreatic tumors. This kind of scintigraphy should be applied in primary tumor localization, staging, and course control in a confirmed or highly probable neuroendocrine gastroenteropancreatic tumor. Furthermore, the use of a gamma probe for intraoperative tumor localization is demonstrated. Therapy with radioactively marked somatostatin analogues should be possible because of the highly selective tumor uptake. The development of an optimal tracer is the subject of current research.

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  1. Department of Radiology and Nuclear Medicine, University Medical Center Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    M. Bäder & K. Koppenhagen

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  1. M. Bäder
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  2. K. Koppenhagen
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  1. Fachbereich Humanmedizin, Univ.-Klinikum Benjamin Franklin, Medizinische Klinik und Poliklinik, Schwerpunkt Hämatologie und Onkologie, Freie Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Ernst-D. Kreuser

  2. Robert-Rössle Klinik am Max-Delbrück-Centrum, Humboldt-Universität, Lindenberger Weg 80, 13122, Berlin, Germany

    P. M. Schlag

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© 1996 Springer-Verlag Berlin Heidelberg

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Bäder, M., Koppenhagen, K. (1996). Somatostatin Receptor Scintigraphy in the Diagnosis of Neuroendocrine Gastroenteropancreatic Tumors. In: Kreuser, ED., Schlag, P.M. (eds) New Perspectives in Molecular and Clinical Management of Gastrointestinal Tumors. Recent Results in Cancer Research, vol 142. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80035-1_10

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  • DOI: https://doi.org/10.1007/978-3-642-80035-1_10

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