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Forschung mit Röntgenstrahlen pp 402–426Cite as

Röntgenstrahlen in der Biochemie

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Zusammenfassung

Von ihren Anfängen an ist es ein Erfolgskonzept der Biochemie gewesen, die biologischen Funktionen auf der Basis chemischer Strukturen zu erklären. So ist unser heutiges Verständnis der Lebenserscheinungen nachhaltig von den Strukturaufklärungen biochemisch relevanter Moleküle beeinflußt worden. Dies gilt insbesondere für die Makromoleküle, die die zentralen Träger biologischer Information und Funktion sind: die Nukleinsäuren und Proteine. Ganz offensichtlich ist die Entschlüsselung ihres Aufbaus notwendige Voraussetzung für das Verständnis ihrer Funktion; M. Perutz schrieb dazu mit Blick auf die Enzyme, einer Klasse von Proteinen, die als biologische Katalysatoren in allen biochemischen Prozessen mitwirken:

„Um die chemischen Grundlagen des Lebens verstehen zu können, müssen wir den Apparat kennen, der komplizierte Pflanzen und Tiere aus einfachen chemischen Verbindungen aufbaut. Welche Werkzeuge besitzen lebende Zellen, um große organische Moleküle in wässrigem Medium bei normalen Temperaturen und in neutraler Lösung aufzubauen, ein Vorhaben, für das der Chemiker wirksame Lösungsmittel, hohe Temperaturen, niedrige Drücke und starke Säuren oder Basen braucht?“ (Perutz 1971).

Gemeinhin sagt man, es gebe Feuer, Wasser, Luft und Erde. Es gebe süß und bitter, heiß und kalt. Gemeinhin sagt man, es gebe eine natürliche Ordnung im Universum. In Wahrheit gibt es nichts als Atome und Leere. Demokrit, 400 v. Chr.

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Authors
  1. Peter Reinemer
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  2. Robert Huber
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Editors and Affiliations

  1. Katharinenhospital, Stuttgart, Deutschland

    Friedrich H. W. Heuck (ehem. Ärztlicher Direktor des Radiologischen Instituts) (ehem. Ärztlicher Direktor des Radiologischen Instituts)

  2. Akademisches Lehrkrankenhaus, Universität Tübingen, Kriegsbergstraße 60, 70174, Stuttgart, Deutschland

    Friedrich H. W. Heuck (ehem. Ärztlicher Direktor des Radiologischen Instituts) (ehem. Ärztlicher Direktor des Radiologischen Instituts)

  3. Institut für Werkstoffkunde I, Universität Karlsruhe (TH), Kaiserstraße 12, 76128, Karlsruhe, Deutschland

    Eckard Macherauch

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Reinemer, P., Huber, R. (1995). Röntgenstrahlen in der Biochemie. In: Heuck, F.H.W., Macherauch, E. (eds) Forschung mit Röntgenstrahlen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78841-3_29

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