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The Pharmacology of Monoclonal Antibodies pp 23–48Cite as

Recombinant Therapeutic Human Monoclonal Antibodies

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 113))

Abstract

Cell fusion techniques have made the generation of rodent monoclonal antibodies (MABs) a routine endeavor (Kohler and Milstein 1975). As early as 1975 the first investigators of this technology recognized the therapeutic and industrial potential of MABs, particularly human monoclonal antibodies (huMABs), yet 18 years later only OKT3 — an anti-T lymphocyte antigen (CD3) murine MAB — is a licensed drug. There are two reasons for this apparent lack of progress: target selection and technical difficulties. Despite this modest beginning a large number of MABs generated primarily by cell fusion are in clinical development (see below). Recent advances using recombinant DNA technology have alleviated many of the technical problems with cell fusion and will accelerate the development of therapeutic huMABs (Larrick et al. 1987).

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Authors
  1. J. W. Larrick
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  2. R. Balint
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Editors and Affiliations

  1. Biopharmaceuticals Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406-0939, USA

    Martin Rosenberg Ph.D. (Vice President and Director) (Vice President and Director)

  2. Department of Molecular Genetics, Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406-0939, USA

    Gordon P. Moore Ph.D. (Director) (Director)

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© 1994 Springer-Verlag Berlin Heidelberg

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Larrick, J.W., Balint, R. (1994). Recombinant Therapeutic Human Monoclonal Antibodies. In: Rosenberg, M., Moore, G.P. (eds) The Pharmacology of Monoclonal Antibodies. Handbook of Experimental Pharmacology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78432-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-78432-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78434-7

  • Online ISBN: 978-3-642-78432-3

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