Abstract
A Novel monofilament bioabsorbable sutures was made from a copolymer of e-caprolactone and L-lactide (Poly(CL-LA)). The Composition weight ratio of L-lactide: e-caprolactone was 85: 15. Initial tensile strength of the 5-0 suture was 838 ±72 gf (knot-pull 600 ±60 gf). An in vivo degradation test using rabbits showed: a poly(CL-LA) suture retains its strength for longer periods than other synthetic monofilament absorbable sutures such as MAXON®and PDS®. %Retention of tensile strength at 4 week was Poly(CL-LA) 83 ±13%, MAXON®36 ±9% PDS®50 ± 15%. At 8 weeks the Poly(CL-LA) was 38.2%, though the MAXON®and PDS®were 0%. The tissue reaction of this suture was not remarkable at any interval. At one year, the Poly(CL-LA) fiber was replaced with Collagen deposition.
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© 1992 Springer-Verlag Berlin Heidelberg
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Nakamura, T., Shimizu, Y., Matsui, T., Okumura, N., Hyon, S.H., Nishiya, K. (1992). A Novel Bioabsorbable Monofilament Surgical Suture Made From (ε -Caprolactone, L-Lactide) Copolymer. In: Planck, H., Dauner, M., Renardy, M. (eds) Degradation Phenomena on Polymeric Biomaterials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77563-5_12
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DOI: https://doi.org/10.1007/978-3-642-77563-5_12
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