Abstract
Ischemia and reperfusion lead to the activation of circulating leukocytes with ensuing accumulation, aggregation, and adhesion to the endothelium of postcapillary venules. Through the release of inflammatory mediators and cytotoxic enzymes and the formation of oxygen free radicals adherent leukocytes contribute to reperfusion injury [1, 2]. Therapeutic approaches such as leukocyte depletion by antineutrophil serum or blockage of leukocyte adhesion by monoclonal antibodies have been shown effectively to improve the outcome of reperfusion injury [3, 4]. Adenosine exerts several anti-inflammatory actions by the inhibition of oxygen free radical formation, release of inflammatory mediators, and leukocyte adherence to cultured endothelial cells [5–7]. These effects are mediated via interaction with the adenosine A2 receptor [5].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Granger DN, Benott JN, Suzuki M, Grisham MB (1989) Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol 257:G683
Mullane KM, Salmon JA, Kraemer R (1986) Leukocyte derived metabolites of arachidonic acid in ischemia-induced myocardial injury. Fed Proc 46:2422
Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN (1987) Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol 253:H699
Simpson PJ, Todd RF, Mickelson JK, Fantone JC et al (1990). Sustained limitation of myocardial reperfusion injury by a monoclonal antibody that alters leukocyte function. Circulation 81:226
Cronstein BN, Rosenstein ED, Kramer SB, Weissmann G, Hirschhorn R (1985) Adenosine: a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2-receptor on human neutrophils. J Immunol 136:1366
Cronstein BN, Levin RI, Belanoff J, Weissmann G, Hirschhorn G (1986) Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells. J Clin Invest 78:760
Peachell PT, Lichtenstein LM, Schleimer RP (1989) Inhibition by adenosine of histamine and leukotriene release from human basophils. Biochem Pharmacol 38:1717
Endrich B, Asaishi K, Götz A, Messmer K (1980) Technical report— a new chamber technique for microvascular studies in unanesthetized hamsters. Res Exp Med 177:125
Zeintl H, Sack F-U, Intaglietta M, Messmer K (1989) Computer assisted leukocyte velocity measurement in intravital microscopy. Int J Microcirc Clin Exp 8:293
Daly JW (1982) Adenosine receptors: targets for future drugs. J Med Chem 25:197
Omann GM, Allen RA, Bokoch GM, Painter RG, Traynor AE, Sklar LA (1987) Signal transduction and cytoskeletal activation in the neutrophil. Physiol Rev 67:285
Birch RE, Polmar SH (1986) Adenosine-induced immunosuppression: the role of the adenosine receptor-adenylate cyclase interaction in the alteration of T-lymphocyte surface phenotype and immunoregulatory function. Int J Immunopharmacol 8:329
Kuypers TW, Roos D. (1989) Leukocyte membrane adhesion proteins LFA-1, CR3 and p 150, 95: a review of functional and regulatory aspects. Res Immunol 140:461
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag, Berlin Heidelberg
About this chapter
Cite this chapter
Nolte, D., Lehr, H.A., Messmer, K. (1993). Adenosine Inhibits Postischemic Leukocyte Adherence to the Endothelium of Postcapillary Venules via A2 Receptor. In: Faist, E., Meakins, J.L., Schildberg, F.W. (eds) Host Defense Dysfunction in Trauma, Shock and Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77405-8_45
Download citation
DOI: https://doi.org/10.1007/978-3-642-77405-8_45
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77407-2
Online ISBN: 978-3-642-77405-8
eBook Packages: Springer Book Archive