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T-Cell Paradigms in Parasitic and Bacterial Infections

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. Stefan H. E. Kaufmann

    1. Dept. of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 155)

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Table of contents (11 papers)

  1. Front Matter

    Pages I-IX
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  2. Schistosoma

    1. Front Matter

      Pages 1-1
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    2. T-Cell Antigens and Epitopes in Schistosomiasis

      • C. Auriault, I. Wolowczuk, M. Damonneville, F. Velge-Roussel, V. Pancré, H. Gras-Masse et al.
      Pages 3-20

    3. Cell-Mediated Immune Response to Schistosomiasis

      • S. L. James, A. Sher
      Pages 21-31

  4. Bacteria

    1. Front Matter

      Pages 95-95
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    2. T-Lymphocytes in Leprosy Lesions

      • V. Mehra, R. L. Modlin
      Pages 97-109

    3. Antigen Reactivity and Autoreactivity: Two Sides of the Cellular Immune Response Induced by Mycobacteria

      • T. H. M. Ottenhoff, R. R. P. de Vries
      Pages 111-121

  5. Antigens and Carriers

    1. Front Matter

      Pages 123-123
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    2. T-Cells, Stress Proteins, and Pathogenesis of Mycobacterial Infections

      • S. H. E. Kaufmann, B. Schoel, A. Wand-Württenberger, U. Steinhoff, M. E. Munk, T. Koga
      Pages 125-141

    3. Prediction and Identification of Bacterial and Parasitic T-Cell Antigens and Determinants

      • J. B. Rothbard, J. R. Lamb
      Pages 143-152

    4. Development of BCG As a Recombinant Vaccine Vehicle

      • W. R. Jacobs Jr., S. B. Snapper, L. Lugosi, B. R. Bloom
      Pages 153-160

  6. Back Matter

    Pages 161-162
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Keywords

About this book

It has been said that the development of vaccines against a variety of infectious diseases is among the greatest triumphs of immunology. Indeed, several pathogens have lost their horror through the availability of effective vaccination measures. Unfortunately, this does not hold true for the pathogens dealt within this volume. Malaria, schistosomiasis, leishmaniasis, leprosy, and tuberculosis together are prevalent in more than 100 countries, and over 400 million persons suffer from these diseases. It is becoming increasingly clear that the failure to control these infections in a satisfactory way is directly related to the complexity oftheir interactions with the immune system. These agents have lived with their hosts for long enough to give both-host and parasite-ample opportunity to develop a highly sophisticated interrelationship. The central role of T lymphocytes both in acquired resistance to and pathogenesis of these microbes is well appreciated. In the beginning it may have been thought that acq uired resistance against infectious agents is nothing but another aspect of the immune response, studied with soluble and particulate antigens. This simple concept has gradually changed, and it has become clear that the viability not only of the immune cells but also of the 'antigens' adds another dimension to the game. Several achievements in cellular immunology and molecular biology have now made it possible to better understand at least some mechanisms in this intricate interplay.

Editors and Affiliations

  • Dept. of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany

    Stefan H. E. Kaufmann

Bibliographic Information

  • Book Title: T-Cell Paradigms in Parasitic and Bacterial Infections

  • Editors: Stefan H. E. Kaufmann

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-74983-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1990

  • Softcover ISBN: 978-3-642-74985-8Published: 29 June 2012

  • eBook ISBN: 978-3-642-74983-4Published: 29 June 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 162

  • Topics: Allergology, Immunology, Medical Microbiology

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