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Therapy of Acute Myelogenous Leukemia in Adults

  • Conference paper
Acute Leukemias II

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 33))

Abstract

At present major issues regarding optimal therapy of acute nonlymphocytic leukemia (ANLL) remain unresolved. Controversial areas include the importance of consolidation and the role of postconsolidation therapy (either conventional or intensive). To investigate these problems the Italian Cooperative Group GIMEMA designed a prospective treatment program based on standard induction therapy with daunorubicin (DNR) plus cytosine arabinoside (Ara-C) followed by intensive consolidation. There-after, patients were randomized in three arms to receive an aggressive postconsolidation treatment with sequential combinations of active agents given in short courses at myelosuppressive doses, conventional maintenance, or no treatment at all. This multi- center trial began in 1982 and was closed to patient entry in May 1987.

Supported in part by a grant from the Italian National Research Council, Special Project “Oncology” CNR No. 87.02801.44, CNR No. 87.01494.04, and MPI 40%

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Author information

Authors and Affiliations

  1. Dept. of Hematology I, University, Rome, Italy

    M. C. Petti

  2. GIMEMA Cooperative Group, Italy

    M. C. Petti, G. Broccia, F. Caronia, F. Di Raimondo, G. Fioritoni, S. Ladogana, G. Leone, V. Liso, M. Musso, A. Neri, A. Peta, N. Petti, L. Resegotti, A. Tabilio, M. L. Vegna & F. Mandelli

Authors
  1. M. C. Petti
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  2. G. Broccia
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  3. F. Caronia
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  4. F. Di Raimondo
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  5. G. Fioritoni
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  6. S. Ladogana
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  7. G. Leone
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  8. V. Liso
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  9. M. Musso
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  10. A. Neri
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  11. A. Peta
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  12. N. Petti
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  13. L. Resegotti
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  14. A. Tabilio
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  15. M. L. Vegna
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  16. F. Mandelli
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Editor information

Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann  & J. Ritter , ,  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Petti, M.C. et al. (1990). Therapy of Acute Myelogenous Leukemia in Adults. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_45

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  • DOI: https://doi.org/10.1007/978-3-642-74643-7_45

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50984-4

  • Online ISBN: 978-3-642-74643-7

  • eBook Packages: Springer Book Archive

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