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Phosphorus Magnetic Resonance Spectroscopy (31P NMR) as a Tool for in Vivo Monitoring of Mitochrondrial Muscle Disorders

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Molecular Basis of Membrane-Associated Diseases

Abstract

Magnetic resonance spectroscopy is a relatively new technique for the study of in vivo biochemistry. It offers a look into several biochemical reactions in normally functioning intact tissues. This chapter will not describe the basic NMR experiment and the various atoms that can be studied by it. For an introduction to the NMR field the reader is referred to monographs on the subject (e.g. Gadian [1]). The chapter will also only briefly describe the basics of phosphorus nuclear magnetic resonance spectroscopy (31P NMR). I will concentrate on the use of 31P NMR in muscle mitochondrial disorders and related conditions. Findings in other disorders of energy metabolism (e.g. glycolytic defects) will not be described. Data on normal functioning muscle will be presented only if they are relevant to mitochondrial diseases.

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Author information

Authors and Affiliations

  1. Department of Neurology, Hadassah University Hospital, Jerusalem, Israel

    Z. Argov

Authors
  1. Z. Argov
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Editor information

Editors and Affiliations

  1. Institut für Biochemie und Molekularbiologie, Universität Bern, Bühlstraße 28, CH-3012, Bern, Switzerland

    Angelo Azzi

  2. Institute of Physiology, Czechoslovak Academy of Sciences, Videnska 1083, CS-142 20, Praha 4, Czech Republic

    Zdenek Drahota

  3. Institute of Medical Biochemistry and Chemistry, University of Bari, Piazza G. Cesare, I-70124, Bari, Italy

    Sergio Papa

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© 1989 Springer-Verlag Berlin Heidelberg

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Argov, Z. (1989). Phosphorus Magnetic Resonance Spectroscopy (31P NMR) as a Tool for in Vivo Monitoring of Mitochrondrial Muscle Disorders. In: Azzi, A., Drahota, Z., Papa, S. (eds) Molecular Basis of Membrane-Associated Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74415-0_17

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  • DOI: https://doi.org/10.1007/978-3-642-74415-0_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74417-4

  • Online ISBN: 978-3-642-74415-0

  • eBook Packages: Springer Book Archive

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