Abstract
It is a great honor and pleasure to be invited to give a lecture at this NATO Symposium in honor of my good friend Victor Whittaker, who seems to me to be far too active and dynamic to be retiring.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Atweh SF, Kuhar MJ (1977a) Autoradiographic localization of opiate receptors in rat brain I. Spinal cord and lower medulla. Brain Res 124: 53–67
Atweh SF, Kuhar MJ (1977b) Autoradiographic localization of opiate receptors in rat brain II. The brainstem. Brain Res 129: 1–12
Atweh SF, Kuhar MJ (1977c) Autoradiographic localization of opiate receptors in rat brain III. The telencephalon. Brain Res 134: 393–406
Bidlack JM, Abood LG (1980) Solubilization of the opiate receptor. Life Sci 27: 331–340
Bidlack JM, Abood LG, Osei-Gyimah P, Archer S (1981) Purification of the opiate receptor from rat brain. Proc Natl Acad Sci USA 78: 636–639
Cardinale GJ, Donnerer J, Finck AD, Katrowitz JD, Oka K, Spector S (1987) Morphine and codeine are endogenous components of human cerebrospinal fluid. Life Sci 40: 301–306
Cho TM, Hasegawa JI, Ge BL, Loh HH (1986) Purification to apparent homogeneity ot a u-type opioid receptor from rat brain. Proc Natl Acad Sci USA 83: 4138–4142
Cho TM Yamato C Cho JS, Loh HH (1981) Solubilization of membrane bound opiate receptors from rat brain. Life Sci 28: 2651–2657
Chow T, Zukin RS (1983) Solubilization and preliminary characterization of mu and kappa opiate receptor subtypes from rat brain. Mol Pharmacol 24: 203–212
Collier HOJ, Roy AC (1974) Hypothesis: Inhibition of E-prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia. Prostaglandins 7: 361–376
Cox BM, Goldstein F, Li CH (1976) Opioid activity of a peptide ß-lipotropin-(61–91) derived from ß-lipotropin. Proc Natl Acad Sci USA 73: 1821–1823
Demoliou-Mason C, Barnard EA (1984) Solubilization in high yield of opioid receptors retaining high affinity delta, mu and kappa binding sites. FEBS Lett 170: 378–382
Donnerer J, Oka K, Brossi A, Rice KC, Spector S (1986) Presence and formation of codeine and morphine in the rat. Proc Natl Acad Sci USA 83: 4566–4567
Gilbert PE, Martin WR (1976) The effects of morphine- and nalorphine-like drugs in the nondependent morphine-dependent and cyclazocine-dependent chronic spinal dog. J Pharmacol Exp Therap 198: 66–82
Gioannini TL, Foucaud B, Hiller JM, Hatten ME, Simon EJ (1982) Lectin binding of solubi1ized opiate receptors: Evidence for the glycoprotein nature. Biochem Biophys Res Commun 105: 1128–1134
Gioannini TL, Howard A, Hiller JM, Simon EJ (1984) Affinity chromatography of solubi1ized opioid binding sites using CH-Sepharose modified with a new naltrexone derivative. Biochem Biophys Res Commu 119: 624–629
Gioannini TL, Howard AD, Hiller JM, Simon EJ (1985) Purification of an active opioid-binding protein from bovine striatum. J Biol Chem 260: 15117–115121
Goldstein A, Barrett RW, James IF, Lowney LI, Weitz CJ, Knipmeyer LL, Rapoport H (1985) Morphine and other opiates from beef brain and adrenal. Proc Natl Acad Sci USA 82: 5203–5207
Goldstein A, Tachibana S, Lowney LI, Hunkapiller M, Hood L (1979) Dynorphin (1–13) an extraordinarily potent opioid peptide. Proc Natl Acad Sci USA 76: 6666–6670
Goldstein A, Fischli W, Lowney LI, Hunkapiller M, Hood L (1981) Porcine pituitary dynorphin: complete amino acid sequence of a biologically active heptadecapeptide. Proc Natl Acad Sci USA 78: 7219–7223
Gubler U (1986) Enkephalin genes In:Habener JF (ed) Molecular cloning of hormone genes. The Humana Press, Clifton, NJ pp 229–276
Hiller JM, Pearson J, Simon EJ (1973) Distribution of stereospecific binding of the potent narcotic analgesic etorphine in the human brain: predominance in the limbic system. Res Commu Chem Pathol Pharmacol 6: 1052–1062
Howard AD, de la Baume S, Gioannini TL, Hiller JM, Simon EJ (1985) Covalent labeling of opioid receptors with radioiodinated human ß-endorphin. J Biol Chem 260: 10833–10839
Howard AD, Same Y, Gioannini TL, Hiller JM, Simon EJ (1986) Identification if distinct binding site subunits of \i and 6 opioid receptors. Biochemistry 25: 357–360
Howells RD, Gioannini TL, Hiller JM, Simon EJ (1982) Solubilization and characterization of active opiate binding sites from mammalian brain. J Pharmacol Exp Ther 222: 629–634
Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR (1975) Identification of two related pentaoeptides from the brain with potent opiate agonist activity. Nature 258: 577–579
Itzhak Y, Hiller JM, Simon EJ (1984) Solubilization and characterization of μ δ and κ opioid binding sites from guinea pig brain: physical separation of K receptors. Proc Natl Acad Sci USA 81: 4217–4221
Keren O, Gioannini TL, Hiller JM, Simon EJ (1986) Affinity crosslinking of 125I-human B-endorphin to cell lines possessing either μ or δ type opioid binding sites. Brain Res in press
Kuhar MJ, Pert CB, Snyder SH (1973) Regional distribution of opiate receptor binding in monkey and human brain. Nature 245: 447–450
Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW (1977) Endogenous opioid peptides: multiple agonists and receptors. Nature 267: 495–499
Mains RE, Eipper BA, Ling N (1977) Common precursor to corticotropins and endorphins. Proc Natl Acad Sci USA 74: 3014–3018
Maneckjee R, Zukin RS, Archer S, Michael J, Osei-Gyimah P (1985)
Purification and characterization of the μ opiate receptor from rat brain using affinity chromatography. Proc Natl Acad Sci USA 82:594–598
Martin HR, Eades CG, Thompson JA, Huppler RE, Gilbert PE (1976) The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Fharmacol Exptl Ther 197: 517–532
Nakanishi S, Inoue A, Kita T, Nakamura M, Chan ACY, Cohen SN, Numa S (1979) Nucleotide sequence of cloned cDNA for bovine corticotropin-B-lipoprotein precursor. Nature 278: 423–427
Numa S (1984) Opioid peptide precursors and their genes. In: Udenfriend S, Meienhofer J (eds) The peptides - analysis synthesis biology, Volume 6 opioid peptides: biology chemistry and genetics. Academic Press, New York, pp 1–23
Oka K, Kantrowitz JD, Spector S (1985) Isolation of morphine from toad skin. Proc Natl Acad Sci USA 82: 1852–1854
Pearson J, Brandeis L, Simon E, Hiller J (1980) Radioautography of binding of tritiated diprenorphin to opiate receptors in the rat. Life Sci 26: 1047–1052
Pert CB, Snyder SH (1973) Opiate receptor:demonstration in nervous tissue. Science 182: 1359–1361
Roberts JL, Herbert E (1977) Characterization of a mommon precursor to corticotropin and B-lipotropin: Cell-free synthesis of the precursor and identification of corticotropin peptides in the molecule. Proc Natl Acad Sci USA 74: 4826–4830
Robson LE, Foote RW, Maurer R, Kosterlitz HW (1984) Opioid binding sites of the kappa- type in guinea pig cerebellum. Neuroscience 12: 621–627
Ruegg UT, Cuenod S, Hiller JM, Gioannini TL, Howells RD, Simon EJ (1981) Characterization and partial purification cf solubi1ized active opiate receptors from toad brain. Proc Natl Acad Sci USA 78: 4635–4638
Ruegg UT, Hiller JM, Simon EJ (1980) Solubilization of an active opiate receptor from Bufo marinus. Eur 3 Pharmacol 64: 367–368
Sharma SK, Klee WA, Nirenberg M (1975) Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proc Natl Acad Sci USA 72: 3092–3096
Simon EJ, Hiller JM, Edelman I (1973) Stereospecific binding of the potent narcotic analgesic 3H-etorphine to rat brain homogenate. Proc Natl Acad Sci USA 70: 1947–1949
Simon EJ, Hiller JM, Edelman I (1975) Solubilization of a stereospecific macromolecular complex from rat brain. Science 190: 389–390
Simonds WF, Burke TR Jr, Rice KC, Jacobson AE, Klee WA (1985) Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. Proc Natl Acad Sci USA 82: 4974–4978
Simonds WF, Koski G, Streaty RA, Hjelmeland LM, Klee WA (1980) Solubilization of active opiate receptors. Proc Natl Acad Sci USA 77: 4623–4627
Stefano GB, Kream RM, Zukin RS (1980) Demonstration of stereospecific opiate binding in the nervous tissue of the marine mollusc Mytilus edulis. Brain Res 181: 440–445
Terenius L (1973) Stereospecific interaction between narcotic analgesics and a synaptic plasma membrane fraction of rat cerebral cortex. Acta Pharmacol Toxicol 32: 317–329
Young WS III, Kuhar MJ (1979) A new method for receptor autoradiography: PH] opioid receptors in rat brain. Brain Res 179: 255–270
Zukin SR, Zukin RS (1979) Specific [3H] phencyclidine binding in rat central nervous system. Proc Natl Acad Sci USA 76: 5372–5376
Valette A, Rouge P, Coulais E, Potonnier G, Gros J, Simon EJ (1987) Interaction with lectin of kappa opiod binding sites solubi1ized from human placenta. Life Sci 40: 535–540
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Simon, E.J. (1988). Recent Studies on Opioid Receptors. In: Zimmermann, H. (eds) Cellular and Molecular Basis of Synaptic Transmission. NATO ASI Series, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73172-3_35
Download citation
DOI: https://doi.org/10.1007/978-3-642-73172-3_35
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73174-7
Online ISBN: 978-3-642-73172-3
eBook Packages: Springer Book Archive