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Gene Therapy pp 53–59Cite as

Application of Tetracycline Regulatable Systems for Gene Therapy

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Part of the book series: NATO ASI Series ((ASIH,volume 105))

Abstract

Many diseases candidates for gene therapy require that the therapeutic gene expression level is controlled in order to ensure biological efficacy and to prevent toxic effects. Various systems have been described which allow transcriptional regulation by artificial chimeric transactivators in mammalian cells. This paper describes the tetracycline regulatable systems and discuss their potential application for gene therapy.

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Authors and Affiliations

  1. Laboratoire Rétrovirus et Transfert Génétique, Institut Pasteur, 28 rue du Docteur Roux, 75724, Paris cedex 15, France

    Delphine Bohl & Jean-Michel Heard

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  1. Delphine Bohl
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  2. Jean-Michel Heard
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Editors and Affiliations

  1. NHGRI, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm. 10C103, Bethesda, MD, 20892-1852, USA

    Kleanthis G. Xanthopoulos

  2. Aurora Biosciences Inc., 11010 Torreyana Road, San Diego, CA, 92121, USA

    Kleanthis G. Xanthopoulos

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© 1998 Springer-Verlag Berlin Heidelberg

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Bohl, D., Heard, JM. (1998). Application of Tetracycline Regulatable Systems for Gene Therapy. In: Xanthopoulos, K.G. (eds) Gene Therapy. NATO ASI Series, vol 105. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72160-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-72160-1_5

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