Abstract
The genotoxic activity of a series of nitroimidazo(2,1-b)thiazoles on strain D 7 of Saccharomyces cerevisiae and the mutagenicity on 5 of the standard strains used in Salmonella typhimurium assay were studied. The experiments on bacteria were carried out without metabolic activation; the yeast test was performed using an Aroclor 1254-induced Sprague-Dawley rat-liver homogenate (S-9).
The nitroimidazo(2,1-b)thiazoles were mutagenic in both the bacteria and yeast systems. A NO2 group at position 5 of the imidazole ring and a double bond in the thiazole ring seem to be necessary in order to have mutagenic effect on frame-shift strains of Salmonella typhimurium and on Saccharomyces cerevisiae D 7.
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© 1985 Springer-Verlag
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Forti, G.C., Hrelia, P., Guerra, M.C., Paolini, M., Barbaro, A.M., Biagi, G.L. (1985). Genotoxic Activity of Nitroimidazo(2,1-b)Thiazole Derivatives in Salmonella Typhimurium and Saccharomyces Cerevisiae Assays. In: Chambers, P.L., Cholnoky, E., Chambers, C.M. (eds) Receptors and Other Targets for Toxic Substances. Archives of Toxicology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69928-3_89
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DOI: https://doi.org/10.1007/978-3-642-69928-3_89
Publisher Name: Springer, Berlin, Heidelberg
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