Abstract
Allyl isothiocyanate (AIT) is a naturally occurring compound in some spices of the Cruciferae family. This study was undertaken to investigate the subacute toxicity. AIT was given in oral doses of 0, 10, 20, or 40 mg/kg (5 days/week) to male rats for up to 6 weeks.
The parameters affected at the high dose level included decreases in body weight, thymus weight, blood glucose and serum globulin level. Haematological examination revealed an increased percentage of neutrophils and a decreased percentage of lymphocytes after treatment for 2 weeks. The relative liver weight was elevated in all test groups after AIT administration for one week. Renal dysfunction was indicated by increased urinary aspartate aminotransferase activity, reduced urine volume and changes in the specific gravity of the urine.
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© 1985 Springer-Verlag
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Lewerenz, H.J., Plass, R., Macholz, R. (1985). Subacute Oral Toxicity of Allyl Isothiocyanate in the Rat. In: Chambers, P.L., Cholnoky, E., Chambers, C.M. (eds) Receptors and Other Targets for Toxic Substances. Archives of Toxicology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69928-3_116
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DOI: https://doi.org/10.1007/978-3-642-69928-3_116
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-13670-5
Online ISBN: 978-3-642-69928-3
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