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Oxazolidinediones

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Book cover Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

Until the introduction of succinimides for therapeutic use in 1960, oxazolidinediones were the drugs of choice in the treatment of petit mal epilepsy. They had been used since 1946. Now the oxazolidinediones are merely of historical interest since their clinical tolerance is unequivocally inferior to that of the succinimides. Nevertheless, their pharmacology deserves detailed consideration since they were the first relatively selective petit mal antiepileptics on which intensive experimental investigations of the type and mechanisms of action were carried out. Several reviews have dealt with oxazolidinediones (Woodbury et al. 1972, 1982; Withrow 1980). For structure-activity relationship see Chap. 9, this volume.

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Authors
  1. R. Kretzschmar
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  2. H. J. Teschendorf
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Editors and Affiliations

  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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© 1985 Springer-Verlag Berlin Heidelberg

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Kretzschmar, R., Teschendorf, H.J. (1985). Oxazolidinediones. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_18

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  • DOI: https://doi.org/10.1007/978-3-642-69518-6_18

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